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Substance Name: 5-Fluorouridine
RN: 316-46-1
UNII: 4K0M952561
InChIKey: FHIDNBAQOFJWCA-UAKXSSHOSA-N

Note

  • Irreversible inhibitor of ribosomal RNA biosynthesis.

Classification Codes

  • Drug / Therapeutic Agent
  • Mutation Data

Molecular Formula

  • C9-H11-F-N2-O6

Molecular Weight

  • 262.192
 
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Names and Synonyms

Name of Substance

  • 5-Fluorouridine

Synonyms

  • 4-24-00-01231 (Beilstein Handbook Reference)
  • 5-Fluorouridine
  • 5-Fur
  • BRN 0033662
  • EINECS 206-260-3
  • Fur
  • NSC 146604
  • UNII-4K0M952561

Systematic Names

  • 5-Fluorouridine
  • Uridine, 5-fluoro-

Registry Numbers

CAS Registry Number

  • 316-46-1

FDA UNII

  • 4K0M952561

System Generated Number

  • 0000316461

Structure Descriptors

InChI

1S/C9H11FN2O6/c10-3-1-12(9(17)11-7(3)16)8-6(15)5(14)4(2-13)18-8/h1,4-6,8,13-15H,2H2,(H,11,16,17)/t4-,5-,6-,8-/m1/s1

InChIKey

FHIDNBAQOFJWCA-UAKXSSHOSA-N

Smiles

n1([C@H]2[C@@H]([C@H](O)[C@H](O2)CO)O)c([nH]c(=O)c(c1)F)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 160mg/kg (160mg/kg)   Cancer Research. Vol. 39, Pg. 2406, 1979.
mouse LD50 intraperitoneal 160mg/kg (160mg/kg) GASTROINTESTINAL: OTHER CHANGES

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Cancer Research. Vol. 39, Pg. 2406, 1979.
mouse LD50 intravenous 250mg/kg (250mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 97, Pg. 470, 1958.
mouse LD50 intravenous 250mg/kg (250mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" Proceedings of the Society for Experimental Biology and Medicine. Vol. 97, Pg. 470, 1958.
mouse LD50 subcutaneous 384mg/kg (384mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" Proceedings of the Society for Experimental Biology and Medicine. Vol. 97, Pg. 470, 1958.
rat LD50 intraperitoneal 400mg/kg (400mg/kg)   Advances in Teratology. Vol. 3, Pg. 181, 1968.