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Substance Name: Thioproperazine [INN:BAN]
RN: 316-81-4
UNII: YJ050AQ56X
InChIKey: VZYCZNZBPPHOFY-UHFFFAOYSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Mutation Data
  • Reproductive Effect

Molecular Formula

  • C22-H30-N4-O2-S2

Molecular Weight

  • 446.637
 
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Names and Synonyms

Name of Substance

  • Thioproperazine
  • Thioproperazine [INN:BAN]
  • Thioproperazine [INN]

Synonyms

  • (Thioproperazine)-2-dimethylsulfamido-(10-(3-1-methylpiperazinyl-4)propyl)-phenothiazine
  • 10H-Phenothiazine-2-sulfonamide, N,N-dimethyl-10-(3-(4-methyl-1-piperazinyl)propyl)-
  • 7843 R.P.
  • Cephalmin
  • EINECS 206-262-4
  • Majeptyl
  • Mazeptyl
  • Megeptil
  • RP 7843
  • SKF 5883
  • Sulfenazin
  • Thioperazine
  • Thioproperazin
  • Thioproperazine
  • Thioproperazinum
  • Thioproperazinum [INN-Latin]
  • Tioproferazina
  • Tioproferazina [INN-Spanish]
  • Tioproperazin
  • Tioproperazina
  • Tioproperazina [DCIT]
  • UNII-YJ050AQ56X
  • Vontil

Systematic Names

  • 10H-Phenothiazine-2-sulfonamide, N,N-dimethyl-10-(3-(4-methyl-1-piperazinyl)propyl)-
  • Phenothiazine-2-sulfonamide, N,N-dimethyl-10-(3-(4-methyl-1-piperazinyl)propyl)-
  • Thioproperazine

Registry Numbers

CAS Registry Number

  • 316-81-4

FDA UNII

  • YJ050AQ56X

System Generated Number

  • 0000316814

Structure Descriptors

InChI

1S/C22H30N4O2S2/c1-23(2)30(27,28)18-9-10-22-20(17-18)26(19-7-4-5-8-21(19)29-22)12-6-11-25-15-13-24(3)14-16-25/h4-5,7-10,17H,6,11-16H2,1-3H3

InChIKey

VZYCZNZBPPHOFY-UHFFFAOYSA-N

Smiles

CN(C)S(=O)(=O)c1ccc2Sc3ccccc3N(CCCN4CCN(C)CC4)c2c1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 130mg/kg (130mg/kg)   Psychopharmacology Service Center, Bulletin. Vol. 2, Pg. 17, 1963.
mouse LD50 intravenous 70mg/kg (70mg/kg)   Psychopharmacology Service Center, Bulletin. Vol. 2, Pg. 17, 1963.
mouse LD50 oral 830mg/kg (830mg/kg) BEHAVIORAL: ANTIPSYCHOTIC Developments in Neuroscience Vol. 7, Pg. 45, 1980.
mouse LD50 subcutaneous 500mg/kg (500mg/kg)   Psychopharmacology Service Center, Bulletin. Vol. 2, Pg. 17, 1963.
rat LD50 intravenous 25mg/kg (25mg/kg)   Therapie. Vol. 18, Pg. 373, 1963.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 140 deg C   EXP
log P (octanol-water) 2.950 (none)   EST
Atmospheric OH Rate Constant 1.72E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.