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Substance Name: Josamycin propionate
RN: 31674-19-8
UNII: 911QFM8O20
InChIKey: NBWASFCRCRXRKF-VGOAISAMSA-N

Note

  • In contrast to josamycin which is bitter, the propionate is tasteless & effective.

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C45-H73-N-O16

Molecular Weight

  • 884.0627
 
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Names and Synonyms

Name of Substance

  • Josamycin propionate

Synonyms

  • BRN 1677122
  • Josamycin propionate
  • Leucomycin V, 3-acetate 4B-(3-methylbutanoate) 2A-propanoate
  • UNII-911QFM8O20

Systematic Name

  • Leucomycin A3, monopropionate (ester)

Registry Numbers

CAS Registry Number

  • 31674-19-8

FDA UNII

  • 911QFM8O20

System Generated Number

  • 0031674198

Structure Descriptors

InChI

1S/C45H73NO16/c1-13-34(50)59-42-38(46(10)11)39(61-37-24-45(9,53)43(29(7)56-37)60-35(51)21-25(2)3)28(6)57-44(42)62-40-31(19-20-47)22-26(4)32(49)18-16-14-15-17-27(5)55-36(52)23-33(41(40)54-12)58-30(8)48/h14-16,18,20,25-29,31-33,37-44,49,53H,13,17,19,21-24H2,1-12H3/b15-14+,18-16+/t26-,27-,28-,29+,31+,32+,33-,37+,38+,39-,40+,41+,42-,43+,44+,45-/m1/s1

InChIKey

NBWASFCRCRXRKF-VGOAISAMSA-N

Smiles

CCC(=O)O[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1O[C@H]2[C@H](C[C@H]([C@H](/C=C/C=C/C[C@H](OC(=O)C[C@H]([C@@H]2OC)OC(=O)C)C)O)C)CC=O)C)O[C@H]3C[C@@]([C@H]([C@@H](O3)C)OC(=O)CC(C)C)(C)O)N(C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD intraperitoneal > 2gm/kg (2000mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Japanese Journal of Antibiotics. Vol. 26, Pg. 136, 1973.
mouse LD oral > 4gm/kg (4000mg/kg)   Japanese Journal of Antibiotics. Vol. 26, Pg. 136, 1973.
mouse LD subcutaneous > 4gm/kg (4000mg/kg)   Japanese Journal of Antibiotics. Vol. 26, Pg. 136, 1973.
rat LD intraperitoneal > 2gm/kg (2000mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Japanese Journal of Antibiotics. Vol. 26, Pg. 136, 1973.
rat LD oral > 4gm/kg (4000mg/kg)   Japanese Journal of Antibiotics. Vol. 26, Pg. 136, 1973.
rat LD subcutaneous > 4gm/kg (4000mg/kg)   Japanese Journal of Antibiotics. Vol. 26, Pg. 136, 1973.