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Substance Name: Drotebanol [INN:BAN:DCF]
RN: 3176-03-2
UNII: 7RS2Q8MCK8
InChIKey: LCAHPIFLPICNRW-SVYNMNNPSA-N

Molecular Formula

  • C19-H27-N-O4

Molecular Weight

  • 333.4253
 

Classification Codes

Classification Codes

  • Analgesics
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Drug / Therapeutic Agent
  • Narcotics
  • Peripheral Nervous System Agents
  • Sensory System Agents

Superlist Classification Code

  • DEA Schedule I
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Names and Synonyms

Name of Substance

  • Drotebanol
  • Drotebanol [INN:BAN:DCF]

Synonyms

  • 14-Hydroxy-6-beta-thebainol 4-methyl ether
  • 14-Hydroxydihydro-6-beta-thebainol 4-methyl ether
  • 3,4-Dimethoxy-17-methylmorphinan-6-beta,14-diol
  • 6-beta,14-Dihydroxy-3,4-dimethoxy-N-methylmorphinan
  • Dihydro-14-hydroxy-4-O-methyl-6-beta-thebainol
  • Dihydro-14-hydroxy-6-beta-thebainol 4 methyl ester
  • Drotebanol
  • Drotebanolum
  • Drotebanolum [INN-Latin]
  • Metebanyl
  • Morphinan, 6-beta,14-dihydroxy-3,4-dimethoxy-N-methyl-
  • Oxymetebanol
  • Oxymethebanol
  • RAM-326
  • UNII-7RS2Q8MCK8

Systematic Names

  • 3,4-Dimethoxy-17-methylmorphinan-6beta,14-diol
  • Morphinan-6-beta,14-diol, 3,4-dimethoxy-17-methyl-

Superlist Names

  • DEA No. 9335
  • Drotebanol

Registry Numbers

CAS Registry Number

  • 3176-03-2

FDA UNII

  • 7RS2Q8MCK8

System Generated Number

  • 0003176032

Structure Descriptors

InChI

1S/C19H27NO4/c1-20-9-8-18-11-13(21)6-7-19(18,22)15(20)10-12-4-5-14(23-2)17(24-3)16(12)18/h4-5,13,15,21-22H,6-11H2,1-3H3/t13-,15-,18-,19-/m1/s1

InChIKey

LCAHPIFLPICNRW-SVYNMNNPSA-N

Smiles

COc1ccc2C[C@H]3N(C)CC[C@@]4(C[C@H](O)CC[C@@]34O)c2c1OC

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 subcutaneous 919mg/kg (919mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 43, 1970.
mouse LD50 intravenous 87mg/kg (87mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 535, 1979.
mouse LD50 oral 697mg/kg (697mg/kg)   Drugs in Japan Vol. -, Pg. 282, 1995.
mouse LD50 subcutaneous 1150mg/kg (1150mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: ANALGESIA
Chemical and Pharmaceutical Bulletin. Vol. 19, Pg. 1, 1971.
rat LD50 intravenous 122mg/kg (122mg/kg)   Drugs in Japan Vol. 6, Pg. 156, 1982.
rat LD50 oral 339mg/kg (339mg/kg)   Drugs in Japan Vol. -, Pg. 282, 1995.
rat LD50 subcutaneous 120mg/kg (120mg/kg)   Drugs in Japan Vol. 6, Pg. 156, 1982.