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Substance Name: Triflusal [INN:BAN]
RN: 322-79-2
UNII: 1Z0YFI05OO
InChIKey: RMWVZGDJPAKBDE-UHFFFAOYSA-N

Note

  • Inhibits platelet aggregation similarly to aspirin.

Molecular Formula

  • C10-H7-F3-O4

Molecular Weight

  • 248.1553
 

Classification Codes

  • Drug / Therapeutic Agent
  • Hematologic Agents
  • Platelet Aggregation Inhibitors
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Names and Synonyms

Name of Substance

  • Triflusal
  • Triflusal [INN:BAN]

Synonyms

  • 2-(Acetyloxy)-4-(trifluoromethyl)benzoic acid
  • 2-Acetoxy-4-trifluoromethylbenzoic acid
  • 4-10-00-00619 (Beilstein Handbook Reference)
  • 4-Trifluoromethylsalicylic acid acetate
  • Aflen
  • alpha,alpha,alpha-Trifluoro-2,4-creosotic acid acetate
  • BRN 2945374
  • Disgren
  • EINECS 206-297-5
  • Grendis
  • Triflusal
  • Triflusalum
  • Triflusalum [INN-Latin]
  • UNII-1Z0YFI05OO
  • UR 1501

Systematic Names

  • 2,4-Cresotic acid, alpha,alpha,alpha-trifluoro-, acetate
  • 2-(Acetyloxy)-4-(trifluoromethyl)benzoic acid
  • 3-Acetoxy-alpha,alpha,alpha-trifluoro-p-toluic acid
  • alpha,alpha,alpha-Trifluoro-2,4-cresotic acid acetate
  • Benzoic acid, 2-(acetyloxy)-4-(trifluoromethyl)- (9CI)

Registry Numbers

CAS Registry Number

  • 322-79-2

FDA UNII

  • 1Z0YFI05OO

System Generated Number

  • 0000322792

Structure Descriptors

InChI

1S/C10H7F3O4/c1-5(14)17-8-4-6(10(11,12)13)2-3-7(8)9(15)16/h2-4H,1H3,(H,15,16)

InChIKey

RMWVZGDJPAKBDE-UHFFFAOYSA-N

Smiles

CC(=O)Oc1cc(ccc1C(=O)O)C(F)(F)F

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 380mg/kg (380mg/kg)   Drugs of the Future. Vol. 3, Pg. 225, 1978.
mouse LD50 oral 437mg/kg (437mg/kg)   Drugs of the Future. Vol. 3, Pg. 225, 1978.
rat LD50 intraperitoneal 217mg/kg (217mg/kg)   Drugs of the Future. Vol. 3, Pg. 225, 1978.
rat LD50 intravenous 228mg/kg (228mg/kg)   Drugs of the Future. Vol. 3, Pg. 225, 1978.
rat LD50 oral 402mg/kg (402mg/kg)   Drugs of the Future. Vol. 3, Pg. 225, 1978.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 121 deg C   EXP
log P (octanol-water) 2.090 (none)   EST
Atmospheric OH Rate Constant 6.75E-13 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.