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Substance Name: Melphalan hydrochloride
RN: 3223-07-2
UNII: 1VXP4V453T
InChIKey: OUUYBRCCFUEMLH-YDALLXLXSA-N
Note
- An alkylating nitrogen mustard that is used as an antineoplastic in the form of the levo isomer - MELPHALAN, the racemic mixture - MERPHALAN, and the dextro isomer - MEDPHALAN; toxic to bone marrow, but little vesicant action; potential carcinogen.
Molecular Formula
- C13-H18-Cl2-N2-O2.Cl-H
Molecular Weight
- 341.6641
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Names and Synonyms
Name of Substance
- Melphalan hydrochloride
Synonyms
- AI3-26377
- Alanine nitrogen mustard hydrochloride
- Alkeran
- Alkeran hydrochloride
- CB 3025 hydrochloride
- L-3-(p-(Bis(2-chloroethyl)amino)phenyl)alanine monohydrochloride
- L-Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-, hydrochloride
- L-Phenylalanine mustard hydrochloride
- L-Sarcolysine hydrochloride
- Melfalan hydrochloride
- Melphalan HCl
- Melphalan hydrochloride
- NSC 8806
- Phenylalanine mustard hydrochloride
- SK 15673
- UNII-1VXP4V453T
Systematic Names
- Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-, monohydrochloride, L-
- L-Phenylalanine, 4-(bis(2-chloroethyl)amino)-, monohydrochloride
Registry Numbers
CAS Registry Number
- 3223-07-2
FDA UNII
- 1VXP4V453T
System Generated Number
- 0003223072
Molecular Formulas
Molecular Formula
- C13-H18-Cl2-N2-O2.Cl-H
Molecular Formula Fragments
- C13-H18-Cl2-N2-O2
- Cl-H
- COMPONENT
Structure Descriptors
InChI
InChI=1S/C13H18Cl2N2O2.ClH/c14-5-7-17(8-6-15)11-3-1-10(2-4-11)9-12(16)13(18)19;/h1-4,12H,5-9,16H2,(H,18,19);1H/t12-;/m0./s1InChIKey
OUUYBRCCFUEMLH-YDALLXLXSA-NSmiles
Cl.N[C@@H](Cc1ccc(cc1)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LDLo | intravenous | 430ug/kg (0.43mg/kg) | BLOOD: LEUKOPENIA BLOOD: OTHER CHANGES BLOOD: THROMBOCYTOPENIA | Cancer Chemotherapy Reports, Part 2. Vol. 2, Pg. 201, 1965. |
dog | LDLo | oral | 4mg/kg (4mg/kg) | BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE BLOOD: AGRANULOCYTOSIS | National Technical Information Service. Vol. PB229-000, |
human | TDLo | oral | 1200ug/kg/5D- (1.2mg/kg) | GASTROINTESTINAL: NAUSEA OR VOMITING | Cancer Chemotherapy Reports, Part 1. Vol. 57, Pg. 369, 1973. |
monkey | LDLo | intravenous | 430ug/kg (0.43mg/kg) | BLOOD: OTHER CHANGES BLOOD: LEUKOPENIA BLOOD: AGRANULOCYTOSIS | Cancer Chemotherapy Reports, Part 2. Vol. 2, Pg. 201, 1965. |
mouse | LD50 | intravenous | 23mg/kg (23mg/kg) | National Technical Information Service. Vol. PB84-162486, |