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Substance Name: Dexfenfluramine [INN:BAN]
RN: 3239-44-9
UNII: E35R3G56OV
InChIKey: DBGIVFWFUFKIQN-VIFPVBQESA-N

Note

  • The S-isomer of FENFLURAMINE. It is a serotonin agonist and is used as an anorectic. Unlike fenfluramine, it does not possess any catecholamine agonist activity.

Molecular Formula

  • C12-H16-F3-N

Molecular Weight

  • 231.2594
 

Classification Codes

Classification Codes

  • Drug / Therapeutic Agent
  • Human Data
  • Neurotransmitter Agents
  • Serotonin Agents
  • Serotonin Receptor Agonists

Superlist Classification Code

  • DEA Schedule IV
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Names and Synonyms

Name of Substance

  • Dexfenfluramine
  • Dexfenfluramine [INN:BAN]

MeSH Heading

  • Dexfenfluramine

Synonyms

  • (+)-Fenfluramine
  • (S)-Fenfluramine
  • Adifax
  • d-Fenfluramine
  • d-N-Ethyl-alpha-methyl-m-trifluoromethylphenethylamine
  • Dexfenfluramina
  • Dexfenfluramina [Spanish]
  • Dexfenfluramine
  • Dexfenfluraminum
  • Dexfenfluraminum [Latin]
  • Dextrofenfluramine
  • HSDB 7356
  • Redux
  • UNII-E35R3G56OV

Systematic Names

  • Benzeneethanamine, N-ethyl-alpha-methyl-3-(trifluoromethyl)-, (S)- (9CI)
  • Phenethylamine, N-ethyl-alpha-methyl-m-(trifluoromethyl)-, (S)-

Superlist Names

  • DEA No. 1670
  • Dexfenfluramine

Registry Numbers

CAS Registry Number

  • 3239-44-9

FDA UNII

  • E35R3G56OV

System Generated Number

  • 0003239449

Structure Descriptors

InChI

1S/C12H16F3N/c1-3-16-9(2)7-10-5-4-6-11(8-10)12(13,14)15/h4-6,8-9,16H,3,7H2,1-2H3/t9-/m0/s1

InChIKey

DBGIVFWFUFKIQN-VIFPVBQESA-N

Smiles

CCN[C@@H](C)Cc1cccc(c1)C(F)(F)F

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 33mg/kg (33mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 161, Pg. 206, 1966.
rat LD50 oral 115mg/kg (115mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 161, Pg. 206, 1966.
women TDLo oral 36mg/kg (36mg/kg) BEHAVIORAL: COMA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP
Annals of Emergency Medicine. Vol. 32, Pg. 102, 1998.