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Substance Name: Butoctamide semisuccinate [JAN]
RN: 32838-28-1
UNII: F58251NT6M
InChIKey: CQONVBIGUJWUFE-UHFFFAOYSA-N

Note

  • Increases REM sleep in chronically prepared cats.

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C16-H29-N-O5

Molecular Weight

  • 315.407
 
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Names and Synonyms

Name of Substance

  • Butoctamide semisuccinate [JAN]
  • Butoctamide succinate

Synonyms

  • Butoctamide hydrogen succinate
  • Butoctamide semisuccinate
  • Listomin S
  • M-2H
  • N-(2-Ethylhexyl)-3-hydroxybutyramide hydrogen succinate
  • N-2-Ethylhexyl-beta-oxybutyramide semisuccinate
  • UNII-F58251NT6M

Systematic Names

  • Butanedioic acid, mono(3-((2-ethylhexyl)amino)-1-methyl-3-oxopropyl) ester (9CI)
  • Succinic acid, monoester with N-(2-ethylhexyl)-3-hydroxybutyramide

Registry Numbers

CAS Registry Number

  • 32838-28-1

FDA UNII

  • F58251NT6M

Related Registry Number

  • 32266-82-3 (calcium salt[2:1])

System Generated Number

  • 0032838281

Structure Descriptors

InChI

1S/C16H29NO5/c1-4-6-7-13(5-2)11-17-14(18)10-12(3)22-16(21)9-8-15(19)20/h12-13H,4-11H2,1-3H3,(H,17,18)(H,19,20)

InChIKey

CQONVBIGUJWUFE-UHFFFAOYSA-N

Smiles

C(CCC(=O)O)(=O)O[C@@H](CC(=O)NC[C@@H](CCCC)CC)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 473mg/kg (473mg/kg)   Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 18, Pg. 648, 1971.
mouse LD50 oral 5600mg/kg (5600mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ATAXIA
Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 18, Pg. 648, 1971.
mouse LD50 subcutaneous 3130mg/kg (3130mg/kg)   Drugs in Japan Vol. -, Pg. 1098, 1995.
rat LD50 intraperitoneal 635mg/kg (635mg/kg)   Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 18, Pg. 648, 1971.
rat LD50 oral 12100mg/kg (12100mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 24, Pg. 2029, 1982.
rat LD50 subcutaneous 2510mg/kg (2510mg/kg)   Drugs in Japan Vol. -, Pg. 1098, 1995.