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Substance Name: Viomycin [INN:BAN]
RN: 32988-50-4
UNII: YVU35998K5
InChIKey: GXFAIFRPOKBQRV-GHXCTMGLSA-N

Note

  • A strongly basic peptide, antibiotic complex from several strains of Streptomyces. It is allergenic and toxic to kidneys and the labyrinth. Viomycin is used in tuberculosis as several different salts and in combination with other agents.

Molecular Formula

  • C25-H43-N13-O10

Molecular Weight

  • 685.6957
 

Classification Codes

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Antibiotics, Antitubercular
  • Antitubercular Agents
  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
  • Natural Product
  • Protein Synthesis Inhibitors
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Viomycin [INN:BAN]

MeSH Heading

  • Viomycin

Synonyms

  • Celiomycin
  • EINECS 251-323-0
  • Florimycin
  • Floromycin
  • Tuberactinomycin B
  • UNII-YVU35998K5
  • Vinacetin A
  • Vioactane
  • Viocin
  • Viomicina
  • Viomicina [INN-Spanish]
  • Viomicina [Italian]
  • Viomycin
  • Viomycine
  • Viomycine [INN-French]
  • Viomycinum
  • Viomycinum [INN-Latin]

Systematic Name

  • Viomycin

Registry Numbers

CAS Registry Number

  • 32988-50-4

FDA UNII

  • YVU35998K5

Other Registry Numbers

  • 11029-36-0
  • 11075-18-6
  • 1390-13-2
  • 18486-75-4
  • 21929-67-9
  • 31674-31-4
  • 33105-23-6
  • 38834-99-0
  • 47870-53-1
  • 7517-94-4

System Generated Number

  • 0032988504

Structure Descriptors

InChI

1S/C25H43N13O10/c26-3-1-2-10(27)4-16(41)32-12-6-30-23(47)18(11-5-17(42)37-24(28)36-11)38-20(44)13(7-31-25(29)48)33-21(45)14(8-39)35-22(46)15(9-40)34-19(12)43/h7,10-12,14-15,17-18,39-40,42H,1-6,8-9,26-27H2,(H,30,47)(H,32,41)(H,33,45)(H,34,43)(H,35,46)(H,38,44)(H3,28,36,37)(H3,29,31,48)/b13-7-/t10-,11+,12-,14-,15-,17-,18-/m0/s1

InChIKey

GXFAIFRPOKBQRV-GHXCTMGLSA-N

Smiles

C1[C@@H](NC(=N)N[C@H]1O)[C@H]2C(=O)NC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N/C(=C\NC(=O)N)/C(=O)N2)CO)CO)NC(=O)C[C@H](CCCN)N

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 oral 1637mg/kg (1637mg/kg)   "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 69, 1982.
rat LD50 intraperitoneal 1075mg/kg (1075mg/kg)   "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 69, 1982.
rat LD50 subcutaneous 1750mg/kg (1750mg/kg)   "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 69, 1982.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) -11.44 (none)   EST
Atmospheric OH Rate Constant 4.31E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.