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Substance Name: Tiaprofenic acid [INN:BAN:DCF:JAN]
RN: 33005-95-7
UNII: 1LS1T6R34C
InChIKey: GUHPRPJDBZHYCJ-UHFFFAOYSA-N

Molecular Formula

  • C14-H12-O3-S

Molecular Weight

  • 260.312
 

Classification Codes

  • Analgesics
  • Analgesics, Non-Narcotic
  • Anti-Inflammatory Agents
  • Anti-Inflammatory Agents, Non-Steroidal
  • Antirheumatic Agents
  • Drug / Therapeutic Agent
  • Human Data
  • Peripheral Nervous System Agents
  • Reproductive Effect
  • Sensory System Agents
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Names and Synonyms

Name of Substance

  • Tiaprofenic acid
  • Tiaprofenic acid [INN:BAN:DCF:JAN]

Synonyms

  • 2-(5-Benzyl-2-thienyl)propionsaeure
  • 5-18-08-00405 (Beilstein Handbook Reference)
  • 5-Benzoyl-alpha-methyl-2-thiopheneacetic acid
  • Acide tiaprofenique
  • Acide tiaprofenique [INN-French]
  • Acido tiaprofenico
  • Acido tiaprofenico [INN-Spanish]
  • Acidum tiaprofenicum
  • Acidum tiaprofenicum [INN-Latin]
  • BRN 1380662
  • EINECS 251-329-3
  • FC 3001
  • RU 15060
  • Surgam
  • Tiaprofenic acid
  • Tiaprofensaeure
  • UNII-1LS1T6R34C

Systematic Names

  • 2-Thiopheneacetic acid, 5-benzoyl-alpha-methyl-
  • 5-Benzoyl-alpha-methyl-2-thiopheneacetic acid
  • Tiaprofenic acid

Registry Numbers

CAS Registry Number

  • 33005-95-7

FDA UNII

  • 1LS1T6R34C

System Generated Number

  • 0033005957

Structure Descriptors

InChI

1S/C14H12O3S/c1-9(14(16)17)11-7-8-12(18-11)13(15)10-5-3-2-4-6-10/h2-9H,1H3,(H,16,17)

InChIKey

GUHPRPJDBZHYCJ-UHFFFAOYSA-N

Smiles

O=C(c1ccccc1)c1sc(cc1)[C@@H](C(=O)O)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 257mg/kg/30D- (257mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION

KIDNEY, URETER, AND BLADDER: "INFLAMMATION, NECROSIS, OR SCARRING OF BLADDER"		 Medical Journal of Australia. Vol. 160, Pg. 123, 1994.
mouse LD50 intraperitoneal 355mg/kg (355mg/kg)   United States Patent Document. Vol. #4159986,
mouse LD50 oral 690mg/kg (690mg/kg) BEHAVIORAL: ANTIPSYCHOTIC Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 715, 1975.
mouse LD50 subcutaneous 675mg/kg (675mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 15, Pg. 688, 1984.
rat LD50 intraperitoneal 225mg/kg (225mg/kg) BEHAVIORAL: ANTIPSYCHOTIC Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 715, 1975.
rat LD50 oral 181mg/kg (181mg/kg) BEHAVIORAL: ANTIPSYCHOTIC Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 715, 1975.
rat LD50 subcutaneous 215mg/kg (215mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 15, Pg. 688, 1984.
women LDLo oral 168mg/kg/14D- (168mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

VASCULAR: SHOCK

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE		 Medical Journal of Australia. Vol. 158, Pg. 647, 1993.
women TDLo oral 16mg/kg/2D-I (16mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

BEHAVIORAL: WAKEFULNESS

BEHAVIORAL: EXCITEMENT		 Canadian Medical Association Journal. Vol. 137, Pg. 1022, 1987.
women TDLo oral 672mg/kg/7W-I (672mg/kg) LIVER: OTHER CHANGES

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ANOREXIA (HUMAN		 Lancet. Vol. 1, Pg. 803, 1986.
women TDLo oral 720mg/kg/60D- (720mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION

KIDNEY, URETER, AND BLADDER: "INFLAMMATION, NECROSIS, OR SCARRING OF BLADDER"		 Medical Journal of Australia. Vol. 160, Pg. 123, 1994.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 96 deg C   EXP
log P (octanol-water) 2.820 (none)   EST
Atmospheric OH Rate Constant 2.45E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.