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Substance Name: Proroxan hydrochloride [USAN]
RN: 33025-33-1
UNII: 694Z9P44G4
InChIKey: QQZPGRDQMBPRFY-UHFFFAOYSA-N

Classification Codes

  • Anti-Adrenergic (alpha-Receptor)
  • Drug / Therapeutic Agent

Molecular Formula

  • C21-H23-N-O3.Cl-H

Molecular Weight

  • 373.878
 
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Names and Synonyms

Name of Substance

  • Proroxan hydrochloride [USAN]

Synonyms

  • 1-(1,4-Benzodioxan-6-yl)-3-(3-phenyl-1-pyrrolidinyl)-1-propanone hydrochloride
  • 6-(3-(3-Phenylpyrrolidinyl)propionyl)-1,4-benzodioxan, hydrochloride
  • AY 24,269
  • AY-24,269
  • Pirroksan
  • Proroxan HCl
  • Proroxan hydrochloride
  • Pyrroxane
  • UNII-694Z9P44G4

Systematic Names

  • 1,4-Benzodioxan, 6-(3-(3-phenylpyrrolidinyl)propionyl)-, hydrochloride
  • 1-Propanone, 1-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-(3-phenyl-1-pyrrolidinyl)-, hydrochloride

Registry Numbers

CAS Registry Number

  • 33025-33-1

FDA UNII

  • 694Z9P44G4

Related Registry Number

  • 33743-96-3 (Parent)

System Generated Number

  • 0033025331

Molecular Formulas

Molecular Formula

  • C21-H23-N-O3.Cl-H

Molecular Formula Fragments

  • C21-H23-N-O3
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C21H23NO3.ClH/c23-19(17-6-7-20-21(14-17)25-13-12-24-20)9-11-22-10-8-18(15-22)16-4-2-1-3-5-16;/h1-7,14,18H,8-13,15H2;1H

InChIKey

QQZPGRDQMBPRFY-UHFFFAOYSA-N

Smiles

c1([C@@H]2C[N@@](CCC(c3cc4c(OCCO4)cc3)=O)CC2)ccccc1.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 140mg/kg (140mg/kg)   Russian Pharmacology and Toxicology Vol. 36, Pg. 172, 1973.
rat LD50 intraperitoneal 100mg/kg (100mg/kg)   Russian Pharmacology and Toxicology Vol. 36, Pg. 172, 1973.