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Substance Name: Enviomycin [INN]
RN: 33103-22-9
UNII: XU299C23A2
InChIKey: HPWIIERXAFODPP-GHBBWTPBSA-N
Note
- Cyclic basic peptide related to VIOMYCIN. It is isolated from an induced mutant of Streptomyces griseoverticillatus var. tuberacticus and acts as an antitubercular agent with less ototoxicity than tuberactinomycin.
Molecular Formula
- C25-H43-N13-O10
Molecular Weight
- 685.6957
Classification Codes
- Anti-Bacterial Agents
- Anti-Infective Agents
- Antibiotics, Antitubercular
- Antitubercular Agents
- Drug / Therapeutic Agent
- Natural Product
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Names and Synonyms
Name of Substance
- Enviomycin
- Enviomycin [INN]
MeSH Heading
- Enviomycin
Synonyms
- Enviomycin
- Enviomycina
- Enviomycina [INN-Spanish]
- Enviomycine
- Enviomycine [INN-French]
- Enviomycinum
- Enviomycinum [INN-Latin]
- tereoisomer of ((15-(3,6-diamino-4-hydroxyhexanamido)-3-(hexahydro-2-imino-4-pyrimidinyl)-9,12-bis(hydroxymethyl-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentaazacyclohexadec-6-ylidene)methyl)urea
- Tuberactinomycin N
- Tuberactinomycin N; stereoisomer of ((15-(3,6-diamino-4-hydroxyhexanamido)-3-(hexahydro-2-imino-4-pyrimidinyl)-9,12-bis(hydroxymethyl-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentaazacyclohexadec-6-ylidene)methyl)urea
- UNII-XU299C23A2
Systematic Names
- Tuberactinomycin N
- Viomycin, 1-((3R,4R)-4-hydroxy-3,6-diaminohexanoic acid)-6-(L-2-(2-amino-1,4,5,6-tetrahydro-4-pyrimidinyl)glycine)-, (R)-
- Viomycin, 1-(threo-4-hydroxy-L-3,6-diaminohexanoic acid)-6-(L-2-(2-amino-1,4,5,6-tetrahydro-4-pyrimidinyl)glycine)-, (R)-
Registry Numbers
CAS Registry Number
- 33103-22-9
FDA UNII
- XU299C23A2
Other Registry Number
- 33987-25-6
System Generated Number
- 0033103229
Structure Descriptors
InChI
1S/C25H43N13O10/c26-3-1-16(41)10(27)5-17(42)33-12-6-31-23(47)18(11-2-4-30-24(28)37-11)38-20(44)13(7-32-25(29)48)34-21(45)14(8-39)36-22(46)15(9-40)35-19(12)43/h7,10-12,14-16,18,39-41H,1-6,8-9,26-27H2,(H,31,47)(H,33,42)(H,34,45)(H,35,43)(H,36,46)(H,38,44)(H3,28,30,37)(H3,29,32,48)/b13-7-/t10-,11-,12+,14+,15+,16-,18+/m1/s1InChIKey
HPWIIERXAFODPP-GHBBWTPBSA-NSmiles
C1CN=C(N[C@H]1[C@H]2C(=O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intramuscular | > 3gm/kg (3000mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 530, 1975. | |
mouse | LD50 | intravenous | 370mg/kg (370mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 530, 1975. | |
mouse | LD50 | oral | > 3gm/kg (3000mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 530, 1975. | |
rat | LD50 | intramuscular | > 2gm/kg (2000mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 530, 1975. | |
rat | LD50 | intravenous | 640mg/kg (640mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 530, 1975. | |
rat | LD50 | oral | > 3gm/kg (3000mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 530, 1975. |