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Substance Name: Etomidate [USAN:USP:INN:BAN]
RN: 33125-97-2
UNII: Z22628B598
InChIKey: NPUKDXXFDDZOKR-LLVKDONJSA-N
Note
- Imidazole derivative anesthetic and hypnotic with little effect on blood gases, ventilation, or the cardiovascular system. It has been proposed as an induction anesthetic.
Molecular Formula
- C14-H16-N2-O2
Molecular Weight
- 244.2924
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Anesthetics
- Anesthetics, General
- Anesthetics, Intravenous
- Central Nervous System Agents
- Central Nervous System Depressants
- Human Data
- Hypnotics and Sedatives
- Sedative-Hypnotic
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Names and Synonyms
Name of Substance
- Etomidate
- Etomidate [USAN:USP:INN:BAN]
MeSH Heading
- Etomidate
Synonyms
- (+)-Ethyl 1-(alpha-methylbenzyl)imidazole-5-carboxylate
- (+)-Etomidate
- (d)-Etomidate
- (R)-(+)-1-(alpha-Methylbenzyl)imidazole-5-carboxylic acid ethyl ester
- 1-(1-Phenylethyl)-1H-imidazole-5-carboxylic acid ethyl ester
- 1-(alpha-Methylbenzyl)-1H-imidazole-5-carboxylic acid ethyl ester
- 1H-Imidazole-5-carboxylic acid, 1-(1-phenylethyl)-, ethyl ester, (R)-
- 5-25-04-00085 (Beilstein Handbook Reference)
- Amidate
- Amidate (pharmaceutical)
- BRN 0665833
- D-Etomidate
- EINECS 251-385-9
- Etomidate
- Etomidato
- Etomidato [INN-Spanish]
- Etomidatum
- Etomidatum [INN-Latin]
- Hypnomidate
- Lipuro
- NSC 759160
- R 16659
- R-(+)-Ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate
- Radenarcon
- UNII-Z22628B598
Systematic Names
- 1H-Imidazole-5-carboxylic acid, 1-((1R)-1-phenylethyl)-, ethyl ester
- 1H-Imidazole-5-carboxylic acid, 1-(1-phenylethyl)-, ethyl ester, (+)-
- 1H-Imidazole-5-carboxylic acid, 1-(1-phenylethyl)-, ethyl ester, (R)-
- Etomidate
- Imidazole-5-carboxylic acid, 1-(alpha-methylbenzyl)-, ethyl ester, (R)-(+)-
Registry Numbers
CAS Registry Number
- 33125-97-2
FDA UNII
- Z22628B598
System Generated Number
- 0033125972
Structure Descriptors
InChI
InChI=1S/C14H16N2O2/c1-3-18-14(17)13-9-15-10-16(13)11(2)12-7-5-4-6-8-12/h4-11H,3H2,1-2H3/t11-/m1/s1InChIKey
NPUKDXXFDDZOKR-LLVKDONJSA-NSmiles
CCOC(=O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
human | TDLo | intravenous | 300ug/kg (0.3mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Anesthesia and Analgesia Vol. 55, Pg. 730, 1976. |
man | TDLo | intravenous | 3977ug/kg/3H- (3.977mg/kg) | BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) | Anesthesia and Analgesia Vol. 64, Pg. 80, 1985. |
mouse | LD50 | intravenous | 29500ug/kg (29.5mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 214, Pg. 92, 1975. |
mouse | LD50 | oral | 650mg/kg (650mg/kg) | Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 65(1), Pg. 19S, 1969. | |
rat | LD50 | intravenous | 14800ug/kg (14.8mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 214, Pg. 92, 1975. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 67 | deg C | EXP | |
log P (octanol-water) | 3.05 | (none) | EXP | |
Water Solubility | 63.2 | mg/L | 25 | EST |
Vapor Pressure | 1.51E-06 | mm Hg | 25 | EST |
Henry's Law Constant | 7.34E-08 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 2.00E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.