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Substance Name: Thiothixene [USAN]
RN: 3313-26-6
UNII: 7318FJ13YJ
InChIKey: GFBKORZTTCHDGY-UWVJOHFNSA-N

Note

  • A thioxanthine used as an antipsychotic agent. Its effects are similar to the phenothiazine antipsychotics.

Molecular Formula

  • C23-H29-N3-O2-S2

Molecular Weight

  • 443.6331
 

Classification Codes

  • Antipsychotic Agents
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Dopamine Agents
  • Dopamine Antagonists
  • Drug / Therapeutic Agent
  • Neurotransmitter Agents
  • Psychotropic Drugs
  • Tranquilizing Agents
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Names and Synonyms

Results Name

  • Thiothixene [USAN]

Name of Substance

  • Thiothixene (Z)
  • Thiothixene [USAN]
  • Tiotixene [INN]

MeSH Heading

  • Thiothixene

Synonyms

  • cis-N,N-Dimethyl-9-(3-(4-methyl-1-piperazinyl)propylidene)thioxanthene-2-sulfonamide
  • cis-Thiothixene
  • NSC-108165
  • Thiothixene
  • Tiotixene
  • Tiotixeno
  • Tiotixeno [INN-Spanish]
  • Tiotixenum
  • Tiotixenum [INN-Latin]
  • UNII-7318FJ13YJ

Systematic Name

  • Thioxanthene-2-sulfonamide, N,N-dimethyl-9-(3-(4-methyl-1-piperazinyl)propylidene)-, (Z)-

Registry Numbers

CAS Registry Number

  • 3313-26-6

FDA UNII

  • 7318FJ13YJ

System Generated Number

  • 0003313266

Structure Descriptors

InChI

1S/C23H29N3O2S2/c1-24(2)30(27,28)18-10-11-23-21(17-18)19(20-7-4-5-9-22(20)29-23)8-6-12-26-15-13-25(3)14-16-26/h4-5,7-11,17H,6,12-16H2,1-3H3/b19-8-

InChIKey

GFBKORZTTCHDGY-UWVJOHFNSA-N

Smiles

CN1CCN(CC1)CC/C=C\2/c3ccccc3Sc4c2cc(cc4)S(=O)(=O)N(C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 100mg/kg (100mg/kg)   Journal of Medicinal Chemistry. Vol. 13, Pg. 17, 1970.
rat LD50 intraperitoneal 55mg/kg (55mg/kg)   Psychopharmacologia Vol. 12, Pg. 142, 1968.