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Substance Name: Telatinib mesylate
RN: 332013-24-8


  • Antineoplastic agent for treatment of advanced solid tumors.

    The orally bioavailable mesylate salt of the 17-allylaminogeldanamycin (17-AAG) small-molecule inhibitor of several receptor protein tyrosine kinases with potential antiangiogenic and antineoplastic activities. Telatinib binds to and inhibits the vascular endothelial growth factor receptors (VEGFRs) type 2 and 3, platelet-derived growth factor receptor beta (PDGFRb) and c-Kit, which may result in the inhibition of angiogenesis and cellular proliferation in tumors in which these receptors are upregulated. These telatinib-inhibited receptor protein tyrosine kinases are overexpressed or mutated in many tumor cell types and may play key roles in tumor angiogenesis and tumor cell proliferation. 17-AAG is a synthetic analogue of the benzoquinone ansamycin antibiotic geldanamycin and has also been found to inhibit the molecular chaperone Hsp90. (NCI Thesaurus)

Molecular Weight

  • 505.937
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Names and Synonyms

Name of Substance

  • Telatinib mesylate


  • Telatinib mesylate
  • Telatinib methanesulfonate

Registry Numbers

CAS Registry Number

  • 332013-24-8

System Generated Number

  • 0332013248

Structure Descriptors