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Substance Name: Telatinib mesylate
RN: 332013-24-8
InChIKey: LCMLACPWPXITHP-UHFFFAOYSA-N

Note

  • Antineoplastic agent for treatment of advanced solid tumors.

    The orally bioavailable mesylate salt of the 17-allylaminogeldanamycin (17-AAG) small-molecule inhibitor of several receptor protein tyrosine kinases with potential antiangiogenic and antineoplastic activities. Telatinib binds to and inhibits the vascular endothelial growth factor receptors (VEGFRs) type 2 and 3, platelet-derived growth factor receptor beta (PDGFRb) and c-Kit, which may result in the inhibition of angiogenesis and cellular proliferation in tumors in which these receptors are upregulated. These telatinib-inhibited receptor protein tyrosine kinases are overexpressed or mutated in many tumor cell types and may play key roles in tumor angiogenesis and tumor cell proliferation. 17-AAG is a synthetic analogue of the benzoquinone ansamycin antibiotic geldanamycin and has also been found to inhibit the molecular chaperone Hsp90. (NCI Thesaurus)

Molecular Weight

  • 505.937
 
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Names and Synonyms

Name of Substance

  • Telatinib mesylate

Synonyms

  • Telatinib mesylate
  • Telatinib methanesulfonate

Registry Numbers

CAS Registry Number

  • 332013-24-8

System Generated Number

  • 0332013248

Structure Descriptors

InChI

1S/C20H16ClN5O3.CH4O3S/c1-22-19(27)16-10-12(6-8-23-16)11-29-20-17-15(7-9-28-17)18(25-26-20)24-14-4-2-13(21)3-5-14;1-5(2,3)4/h2-10H,11H2,1H3,(H,22,27)(H,24,25);1H3,(H,2,3,4)

InChIKey

LCMLACPWPXITHP-UHFFFAOYSA-N

Smiles

CNC(=O)c1cc(ccn1)COc2c3c(cco3)c(nn2)Nc4ccc(cc4)Cl.CS(=O)(=O)O