Substance Name: Abatacept [USAN:INN:BAN:JAN]
RN: 332348-12-6
UNII: 7D0YB67S97
Notes
- A fusion protein immunoconjugate of the extracellular domain of CTLA4 and the Fc domain of human IgG1. It functions as a T-cell co-stimulation blocker that inhibits TNF-ALPHA and prevents the activation of T-LYMPHOCYTES. It is used in the treatment of RHEUMATOID ARTHRITIS.
- BMS-188667 is comprised of two homologous glycosylated polypeptide chains of CTLA4Ig (i.e., a homodimer) of approximately 46 kDa each which are held together by one disulfide bond and non-covalent interactions.
- NLM: Inhibits Tumor Necrosis Factor-alpha; used for Rheumatoid Arthritis; inhibits T-cell function without depleting T cells; called a selective costimulator modulator.
NCI: A soluble fusion protein consisting of the extracellular domain of human cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) linked to a modified Fc (hinge, CH2, and CH3 domains) portion of human immunoglobulin G1 (IgG1) with immunosuppressive activity. See More (NCI Thesaurus)
Molecular Formula
- C1965-H3080-N479-O695-S16
Classification Codes
- Antineoplastic Agents
- Antineoplastic Agents, Immunological
- Antirheumatic
- Antirheumatic Agents
- Immune Checkpoint Inhibitors
- Immunologic Factors
- Immunosuppressive Agents
- Treatment of Autoimmune Diseases such as Rheumatoid Arthritis (Selective Co-Stimulation Modulator; Binds to the B7 Family of Molecules Expressed on Antigen-Presenting Cells (APC))
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Links to Resources
NLM Resources (File Locators)
Other Resources (Internet Locators)
Names and Synonyms
Name of Substance
- Abatacept [USAN:INN:BAN:JAN]
MeSH Heading
- Abatacept
Synonyms
- Abatacept
- BMS 188667
- BMS-188667
- CTLA4-Ig
- CTLA4-Ig B7 Inhibitor
- CTLA4-Ig immunoconjugate
- Cytotoxic T lymphocyte-associated antigen 4
- Cytotoxic T lymphocyte-associated antigen 4-immunoglobulin
- Orencia
- RG 2077
- RG2077
- UNII-7D0YB67S97
Registry Numbers
CAS Registry Number
- 332348-12-6
FDA UNII
- 7D0YB67S97
Other Registry Number
- 213252-14-3
System Generated Number
- 0332348126