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Substance Name: Abatacept [USAN:INN:BAN:JAN]
RN: 332348-12-6
UNII: 7D0YB67S97


  • A fusion protein immunoconjugate of the extracellular domain of CTLA4 and the Fc domain of human IgG1. It functions as a T-cell co-stimulation blocker that inhibits TNF-ALPHA and prevents the activation of T-LYMPHOCYTES. It is used in the treatment of RHEUMATOID ARTHRITIS.
  • BMS-188667 is comprised of two homologous glycosylated polypeptide chains of CTLA4Ig (i.e., a homodimer) of approximately 46 kDa each which are held together by one disulfide bond and non-covalent interactions.
  • NLM: Inhibits Tumor Necrosis Factor-alpha; used for Rheumatoid Arthritis; inhibits T-cell function without depleting T cells; called a selective costimulator modulator.

    NCI: A soluble fusion protein consisting of the extracellular domain of human cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) linked to a modified Fc (hinge, CH2, and CH3 domains) portion of human immunoglobulin G1 (IgG1) with immunosuppressive activity. See More (NCI Thesaurus)

Molecular Formula

  • C1965-H3080-N479-O695-S16

Classification Codes

  • Antineoplastic Agents
  • Antineoplastic Agents, Immunological
  • Antirheumatic
  • Antirheumatic Agents
  • Immune Checkpoint Inhibitors
  • Immunologic Factors
  • Immunosuppressive Agents
  • Treatment of Autoimmune Diseases such as Rheumatoid Arthritis (Selective Co-Stimulation Modulator; Binds to the B7 Family of Molecules Expressed on Antigen-Presenting Cells (APC))

Names and Synonyms

Name of Substance

  • Abatacept [USAN:INN:BAN:JAN]

MeSH Heading

  • Abatacept


  • Abatacept
  • BMS 188667
  • BMS-188667
  • CTLA4-Ig
  • CTLA4-Ig B7 Inhibitor
  • CTLA4-Ig immunoconjugate
  • Cytotoxic T lymphocyte-associated antigen 4
  • Cytotoxic T lymphocyte-associated antigen 4-immunoglobulin
  • Orencia
  • RG 2077
  • RG2077
  • UNII-7D0YB67S97

Registry Numbers

CAS Registry Number

  • 332348-12-6


  • 7D0YB67S97

Other Registry Number

  • 213252-14-3

System Generated Number

  • 0332348126