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Substance Name: Aprindine hydrochloride [USAN:JAN]
RN: 33237-74-0
UNII: PB5EKT7Q2V
InChIKey: KIPFVRHNAAZJOD-UHFFFAOYSA-N

Note

  • A cardiac depressant used in arrhythmias.

Molecular Formula

  • C22-H30-N2.Cl-H

Molecular Weight

  • 358.954
 

Classification Codes

  • Cardiac Depressant (Anti-Arrhythmic)
  • Drug / Therapeutic Agent
  • Human Data
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Aprindine hydrochloride
  • Aprindine hydrochloride [USAN:JAN]

Synonyms

  • 1,3-Propanediamine, N-(2,3-dihydro-1H-inden-2-yl)-N',N'-diethyl-N-phenyl-, monohydrochloride
  • 2-Indanamine, N-(3-(diethylamino)propyl)-N-phenyl-, hydrochloride
  • Amidonal
  • Aprindine HCl
  • Aprindine hydrochloride
  • Aspenon
  • CCRIS 5480
  • Compound 83846
  • EINECS 251-418-7
  • Fibocil
  • Fiboran
  • Lilly 83846
  • MS 5075
  • MS-5075
  • N,N-Diethyl-N'-2-indanyl-N'-phenyl-1,3-propanediamine hydrochloride
  • N,N-Diethyl-N'-2-indanyl-N'-phenyl-1,3-propanediamine monohydrochloride
  • NSC 284614
  • Ritmusin
  • UNII-PB5EKT7Q2V

Systematic Names

  • 1,3-Propanediamine, N,N-diethyl-N'-2-indanyl-N'-phenyl-, monohydrochloride
  • 1,3-Propanediamine, N-(2,3-dihydro-1H-inden-2-yl)-N',N'-diethyl-N-phenyl-, monohydrochloride
  • Aprindine hydrochloride
  • N-(2,3-Dihydro-1H-inden-2-yl)-N',N'-diethyl-N-phenylpropane-1,3-diamine monohydrochloride

Registry Numbers

CAS Registry Number

  • 33237-74-0

FDA UNII

  • PB5EKT7Q2V

System Generated Number

  • 0033237740

Molecular Formulas

Molecular Formula

  • C22-H30-N2.Cl-H

Molecular Formula Fragments

  • C22-H30-N2
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C22H30N2.ClH/c1-3-23(4-2)15-10-16-24(21-13-6-5-7-14-21)22-17-19-11-8-9-12-20(19)18-22;/h5-9,11-14,22H,3-4,10,15-18H2,1-2H3;1H

InChIKey

KIPFVRHNAAZJOD-UHFFFAOYSA-N

Smiles

C1C(Cc2c1cccc2)N(c1ccccc1)CCCN(CC)CC.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 15mg/kg (15mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 32, Pg. 829, 1990.
dog LDLo oral 30mg/kg (30mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Oyo Yakuri. Pharmacometrics. Vol. 27, Pg. 353, 1984.
mouse LD50 intraperitoneal 56600ug/kg (56.6mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Oyo Yakuri. Pharmacometrics. Vol. 27, Pg. 353, 1984.
mouse LD50 intravenous 17100ug/kg (17.1mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Oyo Yakuri. Pharmacometrics. Vol. 27, Pg. 353, 1984.
mouse LD50 oral 262mg/kg (262mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Oyo Yakuri. Pharmacometrics. Vol. 27, Pg. 353, 1984.
mouse LD50 subcutaneous 80200ug/kg (80.2mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 27, Pg. 353, 1984.
mouse LD50 subcutaneous 80200ug/kg (80.2mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Oyo Yakuri. Pharmacometrics. Vol. 27, Pg. 353, 1984.
rat LD50 intraperitoneal 68200ug/kg (68.2mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Oyo Yakuri. Pharmacometrics. Vol. 27, Pg. 353, 1984.
rat LD50 intravenous 16600ug/kg (16.6mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 27, Pg. 353, 1984.
rat LD50 intravenous 16600ug/kg (16.6mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Oyo Yakuri. Pharmacometrics. Vol. 27, Pg. 353, 1984.
rat LD50 oral 525mg/kg (525mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 27, Pg. 353, 1984.
rat LD50 oral 525mg/kg (525mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Oyo Yakuri. Pharmacometrics. Vol. 27, Pg. 353, 1984.
rat LD50 subcutaneous 198mg/kg (198mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Oyo Yakuri. Pharmacometrics. Vol. 27, Pg. 353, 1984.
women TDLo multiple routes 468mg/kg/8W-I (468mg/kg) BLOOD: AGRANULOCYTOSIS Archives of Internal Medicine. Vol. 143, Pg. 229, 1983.
women TDLo unreported 82mg/kg/31D-I (82mg/kg) BLOOD: AGRANULOCYTOSIS Archives of Internal Medicine. Vol. 143, Pg. 241, 1983.