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Substance Name: Buspirone hydrochloride [USAN:USP]
RN: 33386-08-2
UNII: 207LT9J9OC
InChIKey: RICLFGYGYQXUFH-UHFFFAOYSA-N

Note

  • An anxiolytic agent and a serotonin receptor agonist belonging to the azaspirodecanedione class of compounds. Its structure is unrelated to those of the benzodiazepines, but it has an efficacy comparable to DIAZEPAM.

Molecular Formula

  • C21-H31-N5-O2.Cl-H

Molecular Weight

  • 421.9698
 

Classification Codes

  • Drug / Therapeutic Agent
  • Human Data
  • Reproductive Effect
  • Tranquilizer (Minor)

Names and Synonyms

Name of Substance

  • Buspirone hydrochloride [USAN:USP]

Synonyms

  • 1,1-Cyclopentanediacetimide, N-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-, hydrochloride
  • 8-(4-(4-(2-Pyrimidinyl)-1-piperazinyl)butyl)-8-azaspiro(4.5)decane-7,9-dione hydrochloride
  • 8-Azaspiro(4,5)decane-7,9-dione, 8-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-, monohydrochloride
  • Ansitec
  • Anxinil
  • Anxiolan
  • Apo-Buspirone
  • Barpil
  • Biron
  • Busirone
  • Buspar
  • Buspimen
  • Buspinol
  • Buspirone HCl
  • Buspirone hydrochloride
  • Censpar
  • Effiplen
  • EINECS 251-489-4
  • Establix
  • Itagil
  • Kallmiren
  • Lucelan
  • Mabuson
  • MJ 9022-1
  • N-(4-(4-(2-Pyrimidinyl)-1-piperazinyl)butyl)-1,1-cyclopentanediacetamide monohydrochloride
  • Narol
  • Nerbet
  • Normaton
  • Relac
  • Sburol
  • Spamilan
  • Travin
  • Tutran
  • UNII-207LT9J9OC

Systematic Names

  • 8-(4-(4-(2-Pyrimidinyl)-1-piperazinyl)butyl)-8-azaspiro(4.5)decane-7,9-dione monohydrochloride
  • 8-Azaspiro(4,5)decane-7,9-dione, 8-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-, monohydrochloride

Registry Numbers

CAS Registry Number

  • 33386-08-2

FDA UNII

  • 207LT9J9OC

System Generated Number

  • 0033386082

Molecular Formulas

Molecular Formula

  • C21-H31-N5-O2.Cl-H

Molecular Formula Fragments

  • C21-H31-N5-O2
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C21H31N5O2.ClH/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20;/h5,8-9H,1-4,6-7,10-17H2;1H

InChIKey

RICLFGYGYQXUFH-UHFFFAOYSA-N

Smiles

c1cnc(nc1)N2CCN(CC2)CCCCN3C(=O)CC4(CCCC4)CC3=O.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral 586mg/kg (586mg/kg)   Medicamentos de Actualidad. Vol. 23, Pg. 311, 1987.
human TDLo oral 285ug/kg (0.285mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE
Clinical Pharmacology and Therapeutics Vol. 57, Pg. 349, 1995.
mammal (species unspecified) LD50 unreported 140mg/kg (140mg/kg)   Pharmaceutical Chemistry Journal Vol. 25, Pg. 193, 1991.
man TDLo oral 4mg/kg/2W-I (4mg/kg) BEHAVIORAL: EUPHORIA British Journal of Psychiatry. Vol. 158, Pg. 136, 1991.
monkey LD50 oral 356mg/kg (356mg/kg)   Medicamentos de Actualidad. Vol. 23, Pg. 311, 1987.
mouse LD50 intraperitoneal 146mg/kg (146mg/kg) BEHAVIORAL: ANTIPSYCHOTIC

BEHAVIORAL: ALTERATION OF CLASSICAL CONDITIONING
Journal of Medicinal Chemistry. Vol. 15, Pg. 477, 1972.
mouse LD50 oral 655mg/kg (655mg/kg)   Medicamentos de Actualidad. Vol. 23, Pg. 311, 1987.
rat LD50 intraperitoneal 136mg/kg (136mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 917, 1974.
rat LD50 oral 196mg/kg (196mg/kg)   Medicamentos de Actualidad. Vol. 23, Pg. 311, 1987.