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Substance Name: Metaraminol bitartrate [USP:JAN]
RN: 33402-03-8
UNII: ZC4202M9P3
InChIKey: VENXSELNXQXCNT-IJYXXVHRSA-N
Note
- A sympathomimetic agent that acts predominantly at alpha-1 adrenergic receptors. It has been used primarily as a vasoconstrictor in the treatment of HYPOTENSION.
Molecular Formula
- C9-H13-N-O2.C4-H6-O6
Molecular Weight
- 317.2921
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- Registry Numbers
- Formulas
- Structure Descriptors
- Toxicity
Classification Codes
- Antagonist (to Histamine H2 Receptors)
- Drug / Therapeutic Agent
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Names and Synonyms
Name of Substance
- Metaraminol bitartrate (hydrogen l-tartrate)
- Metaraminol bitartrate [USP:JAN]
Synonyms
- (-)-alpha-(1-Aminoethyl)-m-hydroxybenzyl alcohol bitartrate
- (-)-alpha-(1-Aminoethyl)-m-hydroxybenzyl alcohol tartrate (1:1) (salt)
- (-)-Metaraminol bitartrate
- 1-alpha-(1-Aminoethyl)-m-hydroxybenzyl alcohol bitartrate
- 1-alpha-(1-Aminoethyl)-m-hydroxybenzyl alcohol hydrogen d-tartrate
- Aramine
- Aramine (sympathominetic)
- Araminum
- Araminum ampullen
- Benzenemethanol, alpha-(1-aminoethyl)-3-hydroxy-, (R-(R*,S*))-, (R-(R*,R*))-2,3-dihydroxybutanedioate (1:1) (salt)
- Benzyl alcohol, alpha-(1-aminoethyl)-m-hydroxy-, (-)-, tartrate (1:1) (salt)
- EINECS 251-502-3
- IMS metaraminol bitartrat ampullen
- l-1-(m-Hydroxyphenyl)-2-amino-1-propanol-d-hydrogen tartrate
- l-Metraminol bitartrate
- Levicor
- Levicor ampullen
- Metaramin
- Metaraminol (R,R)-hydrogentartrat
- Metaraminol bitartrate
- Metaraminol tartrate (1:1)
- NSC 758425
- Pressonex bitartrate
- Pressorol
- UNII-ZC4202M9P3
Systematic Names
- Benzenemethanol, alpha-((1S)-1-aminoethyl)-3-hydroxy-, (alphaR)-, (2R,3R)-2,3-dihydroxybutanedioate (1:1)
- Benzenemethanol, alpha-(1-aminoethyl)-3-hydroxy-, (R-(R*,S*))-, (R-(R*,R*))-2,3-dihydroxybutanedioate (1:1) (salt)
- Benzyl alcohol, alpha-(1-aminoethyl)-m-hydroxy-, tartrate (1:1), D-(-)-
- Metaraminol hydrogen (+)-tartrate
Registry Numbers
CAS Registry Number
- 33402-03-8
FDA UNII
- ZC4202M9P3
Other Registry Numbers
- 17171-57-2
- 36699-41-9
Related Registry Number
- 54-49-9 (Parent)
System Generated Number
- 0033402038
Molecular Formulas
Molecular Formula
- C9-H13-N-O2.C4-H6-O6
Molecular Formula Fragments
- C4-H6-O6
- C9-H13-N-O2
- COMPONENT
Structure Descriptors
InChI
InChI=1S/C9H13NO2.C4H6O6/c1-6(10)9(12)7-3-2-4-8(11)5-7;5-1(3(7)8)2(6)4(9)10/h2-6,9,11-12H,10H2,1H3;1-2,5-6H,(H,7,8)(H,9,10)/t6-,9-;1-,2-/m01/s1InChIKey
VENXSELNXQXCNT-IJYXXVHRSA-NSmiles
C[C@H](N)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 680mg/kg (680mg/kg) | GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) SKIN AND APPENDAGES (SKIN): HAIR: OTHER | Toxicology and Applied Pharmacology. Vol. 15, Pg. 304, 1969. |
mouse | LD50 | intravenous | 39mg/kg (39mg/kg) | Drugs in Japan Vol. 6, Pg. 820, 1982. | |
mouse | LD50 | oral | 99mg/kg (99mg/kg) | Drugs in Japan Vol. 6, Pg. 820, 1982. | |
rat | LD50 | intraperitoneal | 41mg/kg (41mg/kg) | Drugs in Japan Vol. 6, Pg. 820, 1982. | |
rat | LD50 | intravenous | 3427ug/kg (3.427mg/kg) | VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 281, Pg. 89, 1986. |
rat | LD50 | oral | 240mg/kg (240mg/kg) | Drugs in Japan Vol. 6, Pg. 820, 1982. | |
rat | LD50 | subcutaneous | 117mg/kg (117mg/kg) | Drugs in Japan Vol. 6, Pg. 820, 1982. |