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Substance Name: Gonadorelin [INN:BAN]
RN: 33515-09-2
UNII: 9O7312W37G
InChIKey: XLXSAKCOAKORKW-AQJXLSMYSA-N

Note

  • A decapeptide that stimulates the synthesis and secretion of both pituitary gonadotropins, LUTEINIZING HORMONE and FOLLICLE STIMULATING HORMONE. GnRH is produced by neurons in the septum PREOPTIC AREA of the HYPOTHALAMUS and released into the pituitary portal blood, leading to stimulation of GONADOTROPHS in the ANTERIOR PITUITARY GLAND.

Molecular Formula

  • C55-H75-N17-O13

Molecular Weight

  • 1182.3035
 

Names and Synonyms

Name of Substance

  • Gonadorelin
  • Gonadorelin [INN:BAN]

MeSH Heading

  • Gonadotropin-releasing hormone

Synonyms

  • AY 24031
  • AY-24031
  • Dirigestran
  • Dirigestran Spofa
  • EINECS 251-553-1
  • Fertagyl
  • Follicle-stimulating hormone-releasing factor (pig)
  • Gonadorelin
  • Gonadorelina
  • Gonadorelina [INN-Spanish]
  • Gonadorelinum
  • Gonadorelinum [INN-Latin]
  • Gonadotropin releasing hormone
  • Gonadotropin, luteinizing hormone-releasing hormone, synthetic
  • Gonadotropin-releasing factor
  • Gonadotropin-releasing hormone
  • HOE 471
  • Human LH-RH
  • Hypocrine
  • LH-Releasing factor (pig)
  • LH-Releasing hormone (porcine)
  • LH-RH (swine)
  • Luforan
  • Lutal
  • Lutamin
  • Luteinizing hormone-releasing factor (human)
  • Luteinizing hormone-releasing factor (rat)
  • Luteinizing hormone-releasing factor (sheep)
  • Luteinizing hormone-releasing hormone (swin)
  • Lutrefact
  • Mammalian GnRH
  • Mammalian gonadotropin-releasing hormone
  • Mammalian LH-RH
  • Ovine gonadotropin-releasing hormone
  • Ovine LH-RH
  • p-Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2
  • Porchine LH-RH
  • Porcine LH-releasing factor
  • Relefact
  • Relisorm L
  • Synthetic decapeptide FSH/LH-RH
  • Synthetic Gn-RH
  • Synthetic gonadoliberin
  • Synthetic gonadotropic hormone-releasing hormone
  • Synthetic gonadotropin-releasing hormone
  • Synthetic LH-FSH releasing hormone
  • Synthetic LH-FSH-RH
  • Synthetic LH-releasing factor
  • Synthetic LH-releasing hormone
  • Synthetic LH-releasing hormone/FSH-releasing hormone
  • Synthetic LH-RF
  • Synthetic LH-RH
  • Synthetic LH-RH/FSH-RH
  • Synthetic LRF
  • UNII-9O7312W37G

Systematic Names

  • Glycinamide, 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosylglycyl-L-leucyl-L-arginyl-L-prolyl-
  • Gonadorelin
  • Luteinizing hormone-releasing factor (pig)
  • Luteinizing hormone-releasing factor (swine)

Registry Numbers

CAS Registry Number

  • 33515-09-2

FDA UNII

  • 9O7312W37G

Other Registry Numbers

  • 1092062-05-9
  • 38569-05-0
  • 71339-77-0
  • 9042-18-6
  • 9061-55-6
  • 9066-58-4

Related Registry Numbers

  • 51952-41-1 (Hydrochloride)
  • 52699-48-6 (Acetate)

System Generated Number

  • 0033515092

Structure Descriptors

InChI

1S/C55H75N17O13/c1-29(2)19-38(49(80)67-37(9-5-17-60-55(57)58)54(85)72-18-6-10-43(72)53(84)62-25-44(56)75)66-46(77)26-63-47(78)39(20-30-11-13-33(74)14-12-30)68-52(83)42(27-73)71-50(81)40(21-31-23-61-35-8-4-3-7-34(31)35)69-51(82)41(22-32-24-59-28-64-32)70-48(79)36-15-16-45(76)65-36/h3-4,7-8,11-14,23-24,28-29,36-43,61,73-74H,5-6,9-10,15-22,25-27H2,1-2H3,(H2,56,75)(H,59,64)(H,62,84)(H,63,78)(H,65,76)(H,66,77)(H,67,80)(H,68,83)(H,69,82)(H,70,79)(H,71,81)(H4,57,58,60)/t36-,37-,38-,39-,40-,41-,42-,43-/m0/s1

InChIKey

XLXSAKCOAKORKW-AQJXLSMYSA-N

Smiles

CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc4c[nH]cn4)NC(=O)[C@@H]5CCC(=O)N5)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N6CCC[C@H]6C(=O)NCC(=O)N