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Substance Name: Diflorasone diacetate [USAN:USP:JAN]
RN: 33564-31-7
UNII: 7W2J09SCWX
InChIKey: BOBLHFUVNSFZPJ-JOYXJVLSSA-N

Classification Codes

  • Anti-Inflammatory (Topical)
  • Hormone
  • Reproductive Effect

Molecular Formula

  • C26-H32-F2-O7

Molecular Weight

  • 494.5278
 
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Names and Synonyms

Name of Substance

  • Diflorasone diacetate
  • Diflorasone diacetate [USAN:USP:JAN]

Synonyms

  • 6alpha,9-Difluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17,21-diacetate
  • Apexicon
  • Apexicon e
  • BRN 2318163
  • Diflorasone diacetate
  • EINECS 251-575-1
  • Florone
  • Florone E
  • Maxiflor
  • NSC 759267
  • Psorcon
  • Psorcon E
  • U 34865
  • U-34,865
  • UNII-7W2J09SCWX

Systematic Names

  • 6alpha-Fluorobetamethasone-17,21 diacetate
  • Diflorasone di(acetate)
  • Pregna-1,4-diene-3,20-dione, 17,21-bis(acetyloxy)-6,9-difluoro-11-hydroxy-16-methyl-, (6alpha,11beta,16beta)-

Registry Numbers

CAS Registry Number

  • 33564-31-7

FDA UNII

  • 7W2J09SCWX

System Generated Number

  • 0033564317

Structure Descriptors

InChI

InChI=1S/C26H32F2O7/c1-13-8-17-18-10-20(27)19-9-16(31)6-7-23(19,4)25(18,28)21(32)11-24(17,5)26(13,35-15(3)30)22(33)12-34-14(2)29/h6-7,9,13,17-18,20-21,32H,8,10-12H2,1-5H3/t13-,17-,18-,20-,21-,23-,24-,25-,26-/m0/s1

InChIKey

BOBLHFUVNSFZPJ-JOYXJVLSSA-N

Smiles

C[C@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(OC(=O)C)C(=O)COC(=O)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal > 3gm/kg (3000mg/kg)   Drugs in Japan Vol. -, Pg. 487, 1990.
mouse LD50 oral > 3gm/kg (3000mg/kg)   Drugs in Japan Vol. -, Pg. 487, 1990.
mouse LD50 subcutaneous > 3gm/kg (3000mg/kg)   Drugs in Japan Vol. -, Pg. 487, 1990.
rat LD50 intraperitoneal > 3gm/kg (3000mg/kg)   Drugs in Japan Vol. -, Pg. 487, 1990.
rat LD50 oral > 3gm/kg (3000mg/kg)   Drugs in Japan Vol. -, Pg. 487, 1990.
rat LD50 subcutaneous > 3gm/kg (3000mg/kg)   Drugs in Japan Vol. -, Pg. 487, 1990.