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Substance Name: Clotiazepam [INN:JAN]
RN: 33671-46-4
UNII: ZCN055599V
InChIKey: CHBRHODLKOZEPZ-UHFFFAOYSA-N

Note

  • Thienodiazepine derivative with actions similar to those of benzodiazepines.

Molecular Formula

  • C16-H15-Cl-N2-O-S

Molecular Weight

  • 318.8265
 

Classification Codes

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect

Superlist Classification Code

  • DEA Schedule IV
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Names and Synonyms

Name of Substance

  • Clotiazepam
  • Clotiazepam [INN:JAN]

Synonyms

  • 5-(2-Chlorophenyl)-7-ethyl-1-methyl-1,3-dihydro-2H-thieno(2,3-e)(1,4)diazepin-2-one
  • 5-(o-Chlorophenyl)-7-ethyl-1,3-dihydro-1-methyl-2H-thieno(2,3-e)-1,4-diazepin-2-one
  • BRN 0623332
  • Clotiazepam
  • Clotiazepamum
  • Clotiazepamum [INN-Latin]
  • EINECS 251-627-3
  • Rise
  • Rize
  • Rizen
  • Tienor
  • Trecalmo
  • UNII-ZCN055599V
  • Y 6047

Systematic Names

  • 2H-Thieno(2,3-e)(1,4)diazepin-2-one, 1,3-dihydro-5-(o-chlorophenyl)-7-ethyl-1-methyl-
  • 2H-Thieno(2,3e)(1,4)-diazepin-2-one, 5-(o-chlorophenyl)-7-ethyl-1,3-dihydro-1-methyl- (8CI)
  • 5-(o-Chlorophenyl)-7-ethyl-1,3-dihydro-1-methyl-2H-thieno(2,3-e)-1,4-diazepin-2-one
  • Clotiazepam

Superlist Names

  • Clotiazepam
  • DEA No. 2752

Registry Numbers

CAS Registry Number

  • 33671-46-4

FDA UNII

  • ZCN055599V

System Generated Number

  • 0033671464

Structure Descriptors

InChI

1S/C16H15ClN2OS/c1-3-10-8-12-15(11-6-4-5-7-13(11)17)18-9-14(20)19(2)16(12)21-10/h4-8H,3,9H2,1-2H3

InChIKey

CHBRHODLKOZEPZ-UHFFFAOYSA-N

Smiles

CCc1cc2c(s1)N(C(=O)CN=C2c3ccccc3Cl)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 440mg/kg (440mg/kg)   Journal of Medicinal Chemistry. Vol. 16, Pg. 214, 1973.
mouse LD50 oral 636mg/kg (636mg/kg)   Journal of Medicinal Chemistry. Vol. 16, Pg. 214, 1973.
mouse LD50 subcutaneous 2837mg/kg (2837mg/kg)   Drugs in Japan Vol. 6, Pg. 233, 1982.
rat LD50 intraperitoneal 682mg/kg (682mg/kg)   Drugs in Japan Vol. 6, Pg. 233, 1982.
rat LD50 oral 1461mg/kg (1461mg/kg)   Drugs in Japan Vol. 6, Pg. 233, 1982.
rat LD50 subcutaneous > 5gm/kg (5000mg/kg)   Drugs in Japan Vol. 6, Pg. 233, 1982.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 118-120 deg C   EXP
log P (octanol-water) 3.18 (none)   EXP
Water Solubility 18.3 mg/L 25 EST
Vapor Pressure 3.71E-09 mm Hg 25 EST
Henry's Law Constant 2.90E-09 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 3.13E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.