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Substance Name: Tolcaine hydrochloride
RN: 33697-73-3
UNII: Y31N237ZHH
InChIKey: AGPGNIVJVGCHFO-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C18-H29-N-O2.Cl-H

Molecular Weight

  • 327.893
 
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Names and Synonyms

Results Name

  • Tolcaine hydrochloride

Name of Substance

  • Lotucaine hydrochloride, (-)-

Synonyms

  • (-)-1-(o-Tolossi)-3-(2,2,5,5-tetrametil-pirrolidin-1-il)-propan-2-olo cloridrato
  • (-)-1-(o-Tolossi)-3-(2,2,5,5-tetrametil-pirrolidin-1-il)-propan-2-olo cloridrato [Italian]
  • (-)-2,2,5,5-Tetramethyl-alpha-((o-tolyloxy)methyl)-1-pyrrolidineethanol hydrochloride
  • (-)-Lotucaine hydrochloride
  • MY 33-7
  • Tolcaine hydrochloride
  • UNII-Y31N237ZHH

Systematic Name

  • 1-Pyrrolidineethanol, 2,2,5,5-tetramethyl-alpha-((o-tolyloxy)methyl)-, hydrochloride, (-)-

Registry Numbers

CAS Registry Number

  • 33697-73-3

FDA UNII

  • Y31N237ZHH

System Generated Number

  • 0033697733

Molecular Formulas

Molecular Formula

  • C18-H29-N-O2.Cl-H

Molecular Formula Fragments

  • C18-H29-N-O2
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C18H29NO2.ClH/c1-14-8-6-7-9-16(14)21-13-15(20)12-19-17(2,3)10-11-18(19,4)5;/h6-9,15,20H,10-13H2,1-5H3;1H

InChIKey

AGPGNIVJVGCHFO-UHFFFAOYSA-N

Smiles

N1(C(CCC1(C)C)(C)C)C[C@@H](O)COc1c(cccc1)C.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo intravenous 14mg/kg (14mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 23, Pg. 1596, 1973.
mouse LD50 intravenous 22mg/kg (22mg/kg)   Bollettino Chimico Farmaceutico. Vol. 110, Pg. 330, 1971.
mouse LD50 oral 355mg/kg (355mg/kg)   Bollettino Chimico Farmaceutico. Vol. 110, Pg. 330, 1971.
mouse LD50 subcutaneous 729mg/kg (729mg/kg)   Bollettino Chimico Farmaceutico. Vol. 110, Pg. 330, 1971.
rat LD50 intravenous 32mg/kg (32mg/kg)   Bollettino Chimico Farmaceutico. Vol. 110, Pg. 330, 1971.
rat LD50 oral 418mg/kg (418mg/kg)   Bollettino Chimico Farmaceutico. Vol. 110, Pg. 330, 1971.
rat LD50 subcutaneous 795mg/kg (795mg/kg)   Bollettino Chimico Farmaceutico. Vol. 110, Pg. 330, 1971.