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Substance Name: Dexamethasone valerate [JAN]
RN: 33755-46-3
UNII: OI7CP949NN
InChIKey: SNHRLVCMMWUAJD-OMPPIWKSSA-N

Classification Codes

  • Hormone
  • Reproductive Effect

Molecular Formula

  • C27-H37-F-O6

Molecular Weight

  • 476.581
 
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Names and Synonyms

Name of Substance

  • Dexamethasone 17-valerate
  • Dexamethasone valerate [JAN]

Synonyms

  • Dexamethasone 17-valerate
  • Dexamethasone valerate
  • DV-17
  • EINECS 251-669-2
  • UNII-OI7CP949NN

Systematic Names

  • 9-Fluoro-11beta,17,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 17-valerate
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11-beta,17,21-trihydroxy-16-alpha-methyl-, 17-valerate

Registry Numbers

CAS Registry Number

  • 33755-46-3

FDA UNII

  • OI7CP949NN

System Generated Number

  • 0033755463

Structure Descriptors

InChI

1S/C27H37FO6/c1-5-6-7-23(33)34-27(22(32)15-29)16(2)12-20-19-9-8-17-13-18(30)10-11-24(17,3)26(19,28)21(31)14-25(20,27)4/h10-11,13,16,19-21,29,31H,5-9,12,14-15H2,1-4H3/t16-,19+,20+,21+,24+,25+,26+,27+/m1/s1

InChIKey

SNHRLVCMMWUAJD-OMPPIWKSSA-N

Smiles

C=1C(C=C2[C@@](C)(C1)[C@@]1([C@H]([C@H]3[C@](C)(C[C@@H]1O)[C@](C(=O)CO)(OC(=O)CCCC)[C@@H](C)C3)CC2)F)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 oral > 3gm/kg (3000mg/kg)   Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. Vol. 8, Pg. 23, 1982.
mouse LD50 skin 1784mg/kg (1784mg/kg)   Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. Vol. 8, Pg. 23, 1982.
mouse LD50 subcutaneous 238mg/kg (238mg/kg) BEHAVIORAL: MUSCLE WEAKNESS Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. Vol. 8, Pg. 23, 1982.
rabbit LD50 subcutaneous 100mg/kg (100mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986.
rat LD50 oral > 3gm/kg (3000mg/kg)   Drugs in Japan Vol. -, Pg. 662, 1990.
rat LD50 subcutaneous 117mg/kg (117mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986.