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Substance Name: Oxendolone [USAN:INN:JAN]
RN: 33765-68-3
UNII: MN4I850D4P
InChIKey: FCKLFGKATYPJPG-SSTBVEFVSA-N

Classification Codes

  • Anti-Androgen (Benign Prostatic Hypertrophy)
  • Drug / Therapeutic Agent
  • Hormone
  • Reproductive Effect

Molecular Formula

  • C20-H30-O2

Molecular Weight

  • 302.455
 
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Names and Synonyms

Name of Substance

  • Oxendolone
  • Oxendolone [USAN:INN:JAN]

Synonyms

  • 16-beta-Ethyl-17-beta-hydroxyestr-4-en-3-one
  • 16-beta-Ethyl-19-nortestosterone
  • 16-Ethyl-17-hydroxyester-4-en-3-one
  • 16beta-Ethyl-17beta-hydroxyestr-4-en-3-one
  • Oxendolona
  • Oxendolona [INN-Spanish]
  • Oxendolone
  • Oxendolonum
  • Oxendolonum [INN-Latin]
  • Prostetin
  • TSAA 291
  • TSAA-291
  • UNII-MN4I850D4P

Systematic Names

  • (16beta,17beta)-16-Ethyl-17-hydroxyestr-4-en-3-one
  • Estr-4-en-3-one, 16-beta-ethyl-17-beta-hydroxy-
  • Estr-4-en-3-one, 16-ethyl-17-hydroxy-, (16-beta,17-beta)- (9CI)
  • Estr-4-en-3-one, 16-ethyl-17-hydroxy-, (16beta,17beta)-

Registry Numbers

CAS Registry Number

  • 33765-68-3

FDA UNII

  • MN4I850D4P

System Generated Number

  • 0033765683

Structure Descriptors

InChI

1S/C20H30O2/c1-3-12-11-18-17-6-4-13-10-14(21)5-7-15(13)16(17)8-9-20(18,2)19(12)22/h10,12,15-19,22H,3-9,11H2,1-2H3/t12-,15-,16+,17+,18-,19-,20-/m0/s1

InChIKey

FCKLFGKATYPJPG-SSTBVEFVSA-N

Smiles

CC[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)CC[C@@H]4[C@H]3CC[C@@]2([C@H]1O)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intramuscular > 10gm/kg (10000mg/kg)   Drugs in Japan Vol. 6, Pg. 157, 1982.
mouse LD50 intraperitoneal 2925mg/kg (2925mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ATAXIA

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 7, Pg. 937, 1979.
mouse LD50 oral 5480mg/kg (5480mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 1204, 1981.
mouse LD50 subcutaneous > 10gm/kg (10000mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 23, Pg. 2291, 1981.
rat LD50 intramuscular > 10gm/kg (10000mg/kg)   Drugs in Japan Vol. 6, Pg. 157, 1982.
rat LD50 intraperitoneal 5879mg/kg (5879mg/kg) KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 7, Pg. 937, 1979.
rat LD50 oral 12105mg/kg (12105mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: MUSCLE WEAKNESS
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 7, Pg. 937, 1979.
rat LD50 subcutaneous > 10gm/kg (10000mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 23, Pg. 2291, 1981.