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Substance Name: Triclosan [USAN:USP:INN:BAN]
RN: 3380-34-5
UNII: 4NM5039Y5X
InChIKey: XEFQLINVKFYRCS-UHFFFAOYSA-N
Note
- A diphenyl ether derivative used in cosmetics and toilet soaps as an antiseptic. It has some bacteriostatic and fungistatic action.
Molecular Formula
- C12-H7-Cl3-O2
Molecular Weight
- 289.544
- All
- Classifications
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- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Anti-Infective Agents
- Anti-Infective Agents, Local
- Antimetabolites
- Disinfectant
- Fatty Acid Synthesis Inhibitors
- Hypolipidemic Agents
- Mutation Data
- Reproductive Effect
- Skin / Eye Irritant
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Names and Synonyms
Name of Substance
- 2,4,4'-Trichloro-2'-hydroxy diphenyl ether
- 2,4,4'-Trichloro-2'-hydroxydiphenyl ether
- 5-Chloro-2-(2,4-dichlorophenoxy)phenol
- Phenol, 5-chloro-2-(2,4-dichlorophenoxy)-
- Triclosan
- Triclosan [USAN:USP:INN:BAN]
MeSH Heading
- Triclosan
Synonyms
- 2,4,4'-Trichloro-2'-hydroxydiphenyl ether
- 5-Chloro-2-(2,4-dichlorophenoxy)phenol
- BRN 2057142
- Caswell No. 186A
- CCRIS 9253
- CH 3565
- Cloxifenolum
- DP-300
- EINECS 222-182-2
- EPA Pesticide Chemical Code 054901
- HSDB 7194
- Irgasan
- Irgasan DP300
- Lexol 300
- Neostrata Antibacterial Facial Cleanser
- NSC 759151
- Phenol, 5-chloro-2-(2,4-dichlorophenoxy)-
- Phenyl ether, 2'-hydroxy-2,4,4'-trichloro-
- Stri-Dex Cleansing Bar
- Stri-Dex Face Wash
- Triclosan
- Triclosanum
- Triclosanum [INN-Latin]
- UNII-4NM5039Y5X
Systematic Names
- Ether, 2'-hydroxy-2,4,4'-trichlorodiphenyl
- Phenol, 5-chloro-2-(2,4-dichlorophenoxy)-
- Triclosan
Superlist Name
- 5-Chloro-2-(2,4-dichlorophenoxy)phenol
Registry Numbers
CAS Registry Number
- 3380-34-5
FDA UNII
- 4NM5039Y5X
Other Registry Numbers
- 112099-35-1
- 1155174-27-8
- 164325-69-3
- 261921-78-2
- 88032-08-0
System Generated Number
- 0003380345
Structure Descriptors
InChI
InChI=1S/C12H7Cl3O2/c13-7-1-3-11(9(15)5-7)17-12-4-2-8(14)6-10(12)16/h1-6,16HInChIKey
XEFQLINVKFYRCS-UHFFFAOYSA-NSmiles
Oc1cc(Cl)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 84mg/kg (84mg/kg) | Yakkyoku. Pharmacy. Vol. 28, Pg. 985, 1977. | |
mouse | LD50 | oral | 4530mg/kg (4530mg/kg) | "Pesticides Symposia; Collection of Papers Presented at the Sixth & Seventh Inter-American Conferences on Toxicology and Occupational Medicine, Miami, FL," Miami, FL, J.L. Halos, 1968-70Vol. 6, Pg. 245, 1968/1970. | |
mouse | LD50 | subcutaneous | 3800mg/kg (3800mg/kg) | Yakkyoku. Pharmacy. Vol. 28, Pg. 985, 1977. | |
rabbit | LD50 | skin | 9300mg/kg (9300mg/kg) | Industrial Medicine and Surgery. Vol. 38, Pg. 64, 1969. | |
rat | LD50 | intraperitoneal | 89mg/kg (89mg/kg) | Yakkyoku. Pharmacy. Vol. 28, Pg. 985, 1977. | |
rat | LD50 | intravenous | 29mg/kg (29mg/kg) | Industrial Medicine and Surgery. Vol. 38, Pg. 64, 1969. | |
rat | LD50 | oral | 3700mg/kg (3700mg/kg) | "Pesticides Symposia; Collection of Papers Presented at the Sixth & Seventh Inter-American Conferences on Toxicology and Occupational Medicine, Miami, FL," Miami, FL, J.L. Halos, 1968-70Vol. 6, Pg. 245, 1968/1970. | |
rat | LD50 | subcutaneous | 3900mg/kg (3900mg/kg) | Yakkyoku. Pharmacy. Vol. 28, Pg. 985, 1977. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 54-57.3 | deg C | EXP | |
log P (octanol-water) | 4.76 | (none) | EXP | |
Water Solubility | 10 | mg/L | 20 | EXP |
Vapor Pressure | 6.45E-07 | mm Hg | 25 | EST |
Henry's Law Constant | 4.99E-09 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 1.61E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.