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Substance Name: Flunisolide [INN]
RN: 3385-03-3
UNII: 78M02AA8KF
InChIKey: XSFJVAJPIHIPKU-XWCQMRHXSA-N

Note

  • Flunisolide HFA is a formulation of flunisolide using hydrofluoroalkane (HFA) as propellant, developed to comply with the mandated worldwide phase-out of ozone-depleting chlorofluorocarbon (CFC) propellants.

Molecular Formula

  • C24-H31-F-O6

Molecular Weight

  • 434.5009
 

Classification Codes

  • Anti-Asthmatic Agents
  • Anti-Inflammatory Agents
  • Human Data
  • Reproductive Effect
  • Respiratory System Agents

Names and Synonyms

Name of Substance

  • Flunisolide
  • Flunisolide [INN]

Synonyms

  • Aerobid
  • Aerobid M
  • Aerospan
  • Aerospan HFA
  • Bronalide
  • EINECS 222-193-2
  • Flunisolida
  • Flunisolida [INN-Spanish]
  • Flunisolide
  • Flunisolide HFA
  • Flunisolidum
  • Flunisolidum [INN-Latin]
  • Lunis
  • lunisolide anhydrous
  • Nasalide
  • Nasarel
  • Nisolid
  • Rhinalar
  • RS 3999
  • Soluzione
  • Synaclyn
  • Syntaris
  • UNII-78M02AA8KF

Systematic Names

  • 6alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16, 17-acetal with acetone
  • Flunisolide
  • Pregna-1,4-diene-3,20-dione, 6-alpha-fluoro-11-beta,16-alpha,17,21-tetrahydroxy-, cyclic 16,17-acetal with acetone
  • Pregna-1,4-diene-3,20-dione, 6-fluoro-11,21-dihydroxy-16,17-((1-methylethylidene)bis(oxy))-, (6alpha,11beta,16alpha)-

Superlist Name

  • Flunisolide

Registry Numbers

CAS Registry Number

  • 3385-03-3

FDA UNII

  • 78M02AA8KF

System Generated Number

  • 0003385033

Structure Descriptors

InChI

1S/C24H31FO6/c1-21(2)30-19-9-14-13-8-16(25)15-7-12(27)5-6-22(15,3)20(13)17(28)10-23(14,4)24(19,31-21)18(29)11-26/h5-7,13-14,16-17,19-20,26,28H,8-11H2,1-4H3/t13-,14-,16-,17-,19+,20+,22-,23-,24+/m0/s1

InChIKey

XSFJVAJPIHIPKU-XWCQMRHXSA-N

Smiles

C[C@]12C[C@@H]([C@H]3[C@H]([C@@H]1C[C@@H]4[C@]2(OC(O4)(C)C)C(=O)CO)C[C@@H](C5=CC(=O)C=C[C@]35C)F)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TCLo inhalation 21mg/kg/30W-I (21mg/kg) SENSE ORGANS AND SPECIAL SENSES: DEVIATED NASAL SEPTUM: OLFACTION

SENSE ORGANS AND SPECIAL SENSES: ULCERATED NASAL SEPTUM: OLFACTION
Journal of Pediatrics. Vol. 105, Pg. 840, 1984.
mouse LD50 intravenous > 76ug/kg (0.076mg/kg) BLOOD: APLASTIC ANEMIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 26, Pg. 501, 1984.
mouse LD50 oral > 500ug/kg (0.5mg/kg) BLOOD: APLASTIC ANEMIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 26, Pg. 501, 1984.
mouse LD50 subcutaneous > 290ug/kg (0.29mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BLOOD: APLASTIC ANEMIA
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 26, Pg. 501, 1984.
rat LD50 intravenous > 51mg/kg (51mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 26, Pg. 501, 1984.
rat LD50 intravenous > 51mg/kg (51mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BLOOD: APLASTIC ANEMIA
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 26, Pg. 501, 1984.
rat LD50 oral > 500ug/kg (0.5mg/kg) BLOOD: APLASTIC ANEMIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 26, Pg. 501, 1984.
rat LD50 subcutaneous > 46mg/kg (46mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BLOOD: APLASTIC ANEMIA
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 26, Pg. 501, 1984.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 2.660 (none)   EST
Atmospheric OH Rate Constant 8.43E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.