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Substance Name: Cytochrome P450 17A1
RN: 338964-08-2


  • A microsomal cytochrome P450 enzyme that catalyzes the 17-alpha-hydroxylation of progesterone or pregnenolone and subsequent cleavage of the residual two carbons at C17 in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP17 gene, generates precursors for glucocorticoid, androgen, and estrogen synthesis. Defects in CYP17 gene cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL) and abnormal sexual differentiation.
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Names and Synonyms

Name of Substance

  • Cytochrome P450 17A1

MeSH Heading

  • Steroid 17-alpha-Hydroxylase


  • 17-alpha-Hydroxyprogesterone aldolase
  • CYP17
  • Cyp17a1
  • Cypxvii
  • Cytochrome P450 17A1
  • S17AH
  • Steroid 17-alpha-hydroxylase/17,20 lyase
  • Steroid 17-alpha-monooxygenase

Registry Numbers

CAS Registry Number

  • 338964-08-2


  • 6X5FNK3DCM

System Generated Number

  • 0338964082