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Substance Name: Orphenadrine hydrochloride
RN: 341-69-5
UNII: UBY910DUXH
InChIKey: UQZKYYIKWZOKKD-UHFFFAOYSA-N

Note

  • A muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm.

Molecular Formula

  • C18-H23-N-O.Cl-H

Molecular Weight

  • 305.847
 

Classification Codes

  • Drug / Therapeutic Agent
  • Human Data
  • Reproductive Effect
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Names and Synonyms

Results Name

  • Orphenadrine hydrochloride

Name of Substance

  • Orphenadrine hydrochloride

Synonyms

  • 2-Dimethylaminoethyl 2-methylbenzhydryl ether hydrochloride
  • BF 5930
  • BG 5930
  • Brocadisipal
  • BS 5930
  • Disipal
  • EINECS 206-435-4
  • Mebedrol
  • Mefenamin hydrochloride
  • Mephenamin
  • Mephenamin forte
  • Mephenamin hydrochloride
  • Mephenamine
  • Mephenamine hydrochloride
  • N,N-Dimethyl-2-(o-methyl-alpha-phenylbenzyloxy)ethylamine hydrochloride
  • NSC 82357
  • Orfenadrin hydrochloride
  • Orphenadrine HCl
  • Orphenadrine hydrochloride
  • UNII-UBY910DUXH

Systematic Names

  • Ethanamine, N,N-dimethyl-2-((2-methylphenyl)phenylmethoxy)-, hydrochloride
  • Ethanamine, N,N-dimethyl-2-((2-methylphenyl)phenylmethoxy)-, hydrochloride (9CI)
  • Ethylamine, N,N-dimethyl-2-((o-methyl-alpha-phenylbenzyl)oxy)-, hydrochloride
  • Orphenadrine hydrochloride

Registry Numbers

CAS Registry Number

  • 341-69-5

FDA UNII

  • UBY910DUXH

Related Registry Number

  • 83-98-7 (Parent)

System Generated Number

  • 0000341695

Molecular Formulas

Molecular Formula

  • C18-H23-N-O.Cl-H

Molecular Formula Fragments

  • C18-H23-N-O
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

InChI=1S/C18H23NO.ClH/c1-15-9-7-8-12-17(15)18(20-14-13-19(2)3)16-10-5-4-6-11-16;/h4-12,18H,13-14H2,1-3H3;1H

InChIKey

UQZKYYIKWZOKKD-UHFFFAOYSA-N

Smiles

Cl.CN(C)CCOC(c1ccccc1)c2ccccc2C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child LDLo oral 33mg/kg (33mg/kg) BRAIN AND COVERINGS: INCREASED INTRACRANIAL PRESSURE Archiv fuer Toxikologie. Vol. 25, Pg. 76, 1969.
guinea pig LD50 subcutaneous 74mg/kg (74mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 177, Pg. 28, 1969.
man TDLo oral 71mg/kg (71mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE
Human Toxicology. Vol. 4, Pg. 331, 1985.
mouse LD50 intraperitoneal 65mg/kg (65mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 373, 1972.
mouse LD50 intravenous 20mg/kg (20mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 72, 1955.
mouse LD50 oral 100mg/kg (100mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 72, 1955.
mouse LD50 subcutaneous 88mg/kg (88mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 373, 1972.
rat LD50 intraperitoneal 93mg/kg (93mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION Archives Internationales de Pharmacodynamie et de Therapie. Vol. 177, Pg. 28, 1969.
rat LD50 intravenous 27500ug/kg (27.5mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: ATAXIA
Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 72, 1955.
rat LD50 oral 255mg/kg (255mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Gendai no Rinsho. Vol. 2, Pg. 311, 1968.
rat LD50 subcutaneous 230mg/kg (230mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 72, 1955.
women TDLo oral 150mg/kg (150mg/kg) BEHAVIORAL: COMA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Archiv fuer Toxikologie. Vol. 23, Pg. 264, 1968.