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Substance Name: Sunitinib malate [USAN]
RN: 341031-54-7
UNII: LVX8N1UT73
InChIKey: LBWFXVZLPYTWQI-IPOVEDGCSA-N

Note

  • Inhibits VEGF-R2 and PDGF-Rbeta tyrosine kinase; has antineoplastic activity.

    NCI: sunitinib listen (soo-NIH-tih-nib) A drug used to treat certain types of pancreatic cancer. It is also used to treat gastrointestinal stromal tumors (GIST) in some patients and to treat advanced kidney cancer. It is being studied in the treatment of other types of cancer. Sunitinib stops cancer cells from dividing and may prevent the growth of new blood vessels that tumors need to grow. It is a type of tyrosine kinase inhibitor and a type of angiogenesis inhibitor. Also called SU011248, SU11248, sunitinib malate, and Sutent.

Molecular Formula

  • C22-H27-F-N4-O2.C4-H6-O5

Molecular Weight

  • 532.5657
 

Classification Codes

  • Angiogenesis Inhibitors
  • Angiogenesis Modulating Agents
  • Antineoplastic Agents
  • Growth Substances
  • Treatment of Cancer

Names and Synonyms

Name of Substance

  • Sunitinib malate [USAN]

Synonyms

  • PHA-290940AD
  • SU 011248
  • SU010398
  • SU011248
  • SU011248 L-malate salt
  • Sunitinib malate
  • Sutent
  • UNII-LVX8N1UT73

Systematic Names

  • 1H-Pyrrole-3-carboxamide, N-(2-(diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-, (2S)-hydroxybutanedioate (1:1)
  • Butanedioic acid, hydroxy-, (2S)-, compd. with N-(2-(diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide (1:1)

Registry Numbers

CAS Registry Number

  • 341031-54-7

FDA UNII

  • LVX8N1UT73

System Generated Number

  • 0341031547

Molecular Formulas

Molecular Formula

  • C22-H27-F-N4-O2.C4-H6-O5

Molecular Formula Fragments

  • C22-H27-F-N4-O2
  • C4-H6-O5
  • COMPONENT

Structure Descriptors

InChI

1S/C22H27FN4O2.C4H6O5/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28;5-2(4(8)9)1-3(6)7/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28);2,5H,1H2,(H,6,7)(H,8,9)/b17-12-;/t;2-/m.0/s1

InChIKey

LBWFXVZLPYTWQI-IPOVEDGCSA-N

Smiles

c1c(F)cc2\C(C(Nc2c1)=O)=C\c1[nH]c(c(C(NCCN(CC)CC)=O)c1C)C.C([C@@H](C(=O)O)O)C(O)=O