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Substance Name: Ethylhydrocupreine hydrochloride [NF]
RN: 3413-58-9
UNII: S3N0JB4FC7
InChIKey: QNRATNLHPGXHMA-XZHTYLCXSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Human Data

Molecular Formula

  • C21-H28-N2-O2.Cl-H

Molecular Weight

  • 376.9251
 
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Names and Synonyms

Name of Substance

  • Ethylhydrocupreine hydrochloride [NF]

Synonyms

  • EINECS 222-302-3
  • Ethylhydrocupreine HCl
  • Ethylhydrocupreine hydrochloride
  • Hydrocupreine, ethyl ester, hydrochloride
  • Hydrocupreine, O-6'-ethyl-, monohydrochloride (VAN)
  • Hydrocupreine, O-ethyl-, hydrochloride
  • Neumolisina
  • NSC 5361
  • Numoquin hydrochloride
  • Optochin hydrochloride
  • Optoquin hydrochloride
  • Optoquinhydrochloride
  • Rhombic
  • UNII-S3N0JB4FC7

Systematic Names

  • Cinchonan-9-ol, 6'-ethoxy-10,11-dihydro-, monohydrochloride, (8alpha,9R)- (9CI)
  • Ethylhydrocupreine hydrochloride
  • Hydrocupreine, O-ethyl-, hydrochloride

Registry Numbers

CAS Registry Number

  • 3413-58-9

FDA UNII

  • S3N0JB4FC7

Related Registry Number

  • 522-60-1 (Parent)

System Generated Number

  • 0003413589

Molecular Formulas

Molecular Formula

  • C21-H28-N2-O2.Cl-H

Molecular Formula Fragments

  • C21-H28-N2-O2
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C21H28N2O2.ClH/c1-3-14-13-23-10-8-15(14)11-20(23)21(24)17-7-9-22-19-6-5-16(25-4-2)12-18(17)19;/h5-7,9,12,14-15,20-21,24H,3-4,8,10-11,13H2,1-2H3;1H/t14-,15-,20-,21+;/m0./s1

InChIKey

QNRATNLHPGXHMA-XZHTYLCXSA-N

Smiles

CC[C@H]1C[N@@]2CC[C@H]1C[C@H]2[C@@H](c3ccnc4c3cc(cc4)OCC)O.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
frog LDLo unreported 300mg/kg (300mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Journal of Pharmacology and Experimental Therapeutics. Vol. 8, Pg. 53, 1916.
man TDLo intravenous 31mg/kg/3D (31mg/kg) SENSE ORGANS AND SPECIAL SENSES: VISUAL FIELD CHANGES: EYE

VASCULAR: REGIONAL OR GENERAL ARTERIOLAR CONSTRICTION
Journal of Pharmacology and Experimental Therapeutics. Vol. 8, Pg. 53, 1916.
mouse LDLo subcutaneous 500mg/kg (500mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Journal of Pharmacology and Experimental Therapeutics. Vol. 8, Pg. 53, 1916.