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Substance Name: Clidanac [INN:JAN]
RN: 34148-01-1
UNII: UA6HM01WAK
InChIKey: OIRAEJWYWSAQNG-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C16-H19-Cl-O2

Molecular Weight

  • 278.7771
 
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Names and Synonyms

Name of Substance

  • Clidanac
  • Clidanac [INN:JAN]

Synonyms

  • (+-)-Clidanac
  • (+-)-TAI 284
  • 6-Chloro-5-cyclohexyl-1-indancarboxylic acid
  • 6-Chloro-5-cyclohexyl-2,3-dihydro-1H-indene-1-carboxylic acid
  • Britai
  • BRN 2057663
  • Clidanac
  • Clidanaco
  • Clidanaco [INN-Spanish]
  • Clidanacum
  • Clidanacum [INN-Latin]
  • dl-Clidanac
  • dl-TAI 284
  • Indanal
  • TAI 284
  • UNII-UA6HM01WAK

Systematic Names

  • 1-Indancarboxylic acid, 6-chloro-5-cyclohexyl-
  • 1H-Indene-1-carboxylic acid, 6-chloro-5-cyclohexyl-2,3-dihydro- (9CI)
  • 6-Chloro-5-cyclohexyl-1-indancarboxylic acid

Registry Numbers

CAS Registry Number

  • 34148-01-1

FDA UNII

  • UA6HM01WAK

Other Registry Number

  • 28968-07-2

System Generated Number

  • 0034148011

Structure Descriptors

InChI

1S/C16H19ClO2/c17-15-9-13-11(6-7-12(13)16(18)19)8-14(15)10-4-2-1-3-5-10/h8-10,12H,1-7H2,(H,18,19)

InChIKey

OIRAEJWYWSAQNG-UHFFFAOYSA-N

Smiles

c1c2c(cc(c1C3CCCCC3)Cl)C(CC2)C(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 oral 400mg/kg (400mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 333, 1973.
mouse LD50 intraperitoneal 500mg/kg (500mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 333, 1973.
mouse LD50 intraperitoneal 500mg/kg (500mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 333, 1973.
mouse LD50 intravenous 150mg/kg (150mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 333, 1973.
mouse LD50 intravenous 212mg/kg (212mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 668, 1981.
mouse LD50 oral 750mg/kg (750mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 333, 1973.
mouse LD50 oral 825mg/kg (825mg/kg)   Drugs in Japan Vol. 6, Pg. 217, 1982.
mouse LD50 subcutaneous 800mg/kg (800mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 333, 1973.
mouse LD50 subcutaneous 860mg/kg (860mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 668, 1981.
rabbit LD50 oral 250mg/kg (250mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 333, 1973.
rabbit LD50 oral 380mg/kg (380mg/kg)   Drugs in Japan Vol. 6, Pg. 217, 1982.
rat LD50 intraperitoneal 50mg/kg (50mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 333, 1973.
rat LD50 intravenous 45mg/kg (45mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 333, 1973.
rat LD50 intravenous 88400ug/kg (88.4mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 668, 1981.
rat LD50 oral 41mg/kg (41mg/kg)   Journal of Medicinal Chemistry. Vol. 15, Pg. 1297, 1972.
rat LD50 subcutaneous 60mg/kg (60mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 333, 1973.
rat LD50 subcutaneous 62700ug/kg (62.7mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 668, 1981.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Boiling Point 151.5 deg C   EXP
log P (octanol-water) 5.740 (none)   EST
Atmospheric OH Rate Constant 1.81E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.