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Substance Name: Foscarnet sodium [USAN]
RN: 34156-56-4
UNII: 964YS0OOG1
InChIKey: ILRVASBWNRYBFD-UHFFFAOYSA-K

Note

  • An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesviruses and HIV.

Molecular Formula

  • C-H3-O5-P.3Na.6H2-O

Molecular Weight

  • 300.0388
 

Names and Synonyms

Name of Substance

  • Foscarnet sodium [USAN]

Synonyms

  • Dihydroxyphosphinecarboxylic acid oxide trisodium salt hexahydrate
  • Foscarnet sodium
  • Foscarnet trisodium hexahydrate
  • Phosphonoformic acid, trisodium salt, hexahydrate
  • Trisodium phosphonoformte hexahydrate
  • UNII-964YS0OOG1

Systematic Names

  • Formic acid, phosphono-, trisodium salt, hexahydrate
  • Phosphinecarboxylic acid, dihydroxy-, oxide, trisodium salt, hexahydrate

Registry Numbers

CAS Registry Number

  • 34156-56-4

FDA UNII

  • 964YS0OOG1

System Generated Number

  • 0034156564

Molecular Formulas

Molecular Formula

  • C-H3-O5-P.3Na.6H2-O

Molecular Formula Fragments

  • C-H3-O5-P
  • COMPONENT
  • H2-O
  • Na

Structure Descriptors

InChI

1S/CH3O5P.3Na.6H2O/c2-1(3)7(4,5)6;;;;;;;;;/h(H,2,3)(H2,4,5,6);;;;6*1H2/q;3*+1;;;;;;/p-3

InChIKey

ILRVASBWNRYBFD-UHFFFAOYSA-K

Smiles

C(=O)([O-])P(=O)([O-])[O-].O.O.O.O.O.O.[Na+].[Na+].[Na+]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD intravenous > 810mg/kg (810mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: NAUSEA OR VOMITING
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 39, Pg. 1927, 1997.
mouse LD50 intravenous 510mg/kg (510mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 39, Pg. 1927, 1997.
rat LD50 intravenous 500mg/kg (500mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 39, Pg. 1927, 1997.