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Substance Name: Lidoflazine [USAN:INN:BAN]
RN: 3416-26-0
UNII: J4ZHN3HBTE
InChIKey: ZBIAKUMOEKILTF-UHFFFAOYSA-N

Note

  • Coronary vasodilator with some antiarrhythmic action.

Molecular Formula

  • C30-H35-F2-N3-O

Molecular Weight

  • 491.6225
 

Classification Codes

  • Calcium Channel Blockers
  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Human Data
  • Membrane Transport Modulators
  • Vasodilator (Coronary)
  • Vasodilator Agents
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Names and Synonyms

Name of Substance

  • Lidoflazine
  • Lidoflazine [USAN:INN:BAN]

MeSH Heading

  • Lidoflazine

Synonyms

  • 1-(4,4-Bis(4-fluorofenil)butil)-4-((2,6-dimetilanilinocarbonil)metil)piperazina
  • 1-(4,4-Bis(4-fluorofenil)butil)-4-((2,6-dimetilanilinocarbonil)metil)piperazina [Italian]
  • 1-Piperazineacetamide, 4-(4,4-bis(4-fluorophenyl)butyl)-N-(2,6-dimethylphenyl)-
  • 4-(4,4-Bis(p-fluorophenyl)butyl)-1-piperazineaceto-2',6'-xylidide
  • 5-23-02-00297 (Beilstein Handbook Reference)
  • Angex
  • BRN 0904339
  • Clinium
  • Corflazine
  • EINECS 222-312-8
  • Klinium
  • Lidoflazin
  • Lidoflazina
  • Lidoflazina [INN-Spanish]
  • Lidoflazina [Italian]
  • Lidoflazine
  • Lidoflazinum
  • Lidoflazinum [INN-Latin]
  • McN-JR 7904
  • McN-JR-7904
  • Ordiflazine
  • R 7904
  • UNII-J4ZHN3HBTE

Systematic Names

  • 1-Piperazineacetamide, 4-(4,4-bis(4-fluorophenyl)butyl)-N-(2,6-dimethylphenyl)-
  • 1-Piperazineaceto-2',6'-xylidide, 4-(4,4-bis(p-fluorophenyl)butyl)-
  • Lidoflazine

Registry Numbers

CAS Registry Number

  • 3416-26-0

FDA UNII

  • J4ZHN3HBTE

System Generated Number

  • 0003416260

Structure Descriptors

InChI

1S/C30H35F2N3O/c1-22-5-3-6-23(2)30(22)33-29(36)21-35-19-17-34(18-20-35)16-4-7-28(24-8-12-26(31)13-9-24)25-10-14-27(32)15-11-25/h3,5-6,8-15,28H,4,7,16-21H2,1-2H3,(H,33,36)

InChIKey

ZBIAKUMOEKILTF-UHFFFAOYSA-N

Smiles

Cc1cccc(c1NC(=O)CN2CCN(CC2)CCCC(c3ccc(cc3)F)c4ccc(cc4)F)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
human TDLo oral 20570ug/kg/8D (20.57mg/kg) CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 923, 1972.
mouse LD50 intravenous 40mg/kg (40mg/kg)   French Demande Patent Document. Vol. #2279383,
mouse LD50 oral > 2gm/kg (2000mg/kg)   Archiv der Pharmazie Vol. 322, Pg. 359, 1989.
rat LD50 intraperitoneal > 3200mg/kg (3200mg/kg)   Farmaco, Edizione Scientifica. Vol. 32, Pg. 461, 1977.
rat LD50 oral > 3200mg/kg (3200mg/kg)   Farmaco, Edizione Scientifica. Vol. 32, Pg. 461, 1977.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 159-161 deg C   EXP
log P (octanol-water) 5.6 (none)   EXP
Water Solubility 100 mg/L 25 EXP
Vapor Pressure 1.75E-13 mm Hg 25 EST
Henry's Law Constant 3.38E-16 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 2.22E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.