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Substance Name: Methindethyrium
RN: 3426-58-2
UNII: N4JMG9AVTJ
InChIKey: OCGHTXCFNFYSEY-UHFFFAOYSA-L

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C22-H31-N3.2Cl

Molecular Weight

  • 408.4139
 
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Names and Synonyms

Results Name

  • Methindethyrium

Name of Substance

  • Methindethyrium

Synonyms

  • 4-(2-(1-Methyl-3-indolyl)ethyl)-1-(3-(trimethylammonio)propyl)pyridinium dichloride
  • Dichlorure de(trimethylammonium-1 (beta-N-methylindoyl-3'') ethyl-4' pyridinium)-3 propane
  • IN 391
  • Isotensen
  • Methindethyrium
  • NSC 19481
  • UNII-N4JMG9AVTJ

Systematic Names

  • Pyridinium, 4-(2-(1-methyl-1H-indol-3-yl)ethyl)-1-(3-(trimethylammonio)propyl)-, dichloride (9CI)
  • Pyridinium, 4-(2-(1-methyl-3-indolyl)ethyl)-1-(3-(trimethylammonio)propyl)-, dichloride

Registry Numbers

CAS Registry Number

  • 3426-58-2

FDA UNII

  • N4JMG9AVTJ

System Generated Number

  • 0003426582

Molecular Formulas

Molecular Formula

  • C22-H31-N3.2Cl

Molecular Formula Fragments

  • C22-H31-N3
  • Cl
  • COMPONENT

Structure Descriptors

InChI

1S/C22H31N3.2ClH/c1-23-18-20(21-8-5-6-9-22(21)23)11-10-19-12-15-24(16-13-19)14-7-17-25(2,3)4;;/h5-6,8-9,12-13,15-16,18H,7,10-11,14,17H2,1-4H3;2*1H/q+2;;/p-2

InChIKey

OCGHTXCFNFYSEY-UHFFFAOYSA-L

Smiles

Cn1cc(c2c1cccc2)CCc3cc[n+](cc3)CCC[N+](C)(C)C.[Cl-].[Cl-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 40mg/kg (40mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Annales Pharmaceutiques Francaises. Vol. 22, Pg. 523, 1964.
mouse LD50 intravenous 12mg/kg (12mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Annales Pharmaceutiques Francaises. Vol. 22, Pg. 523, 1964.
mouse LD50 oral 475mg/kg (475mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Annales Pharmaceutiques Francaises. Vol. 22, Pg. 523, 1964.
rabbit LD50 intraperitoneal 90mg/kg (90mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Annales Pharmaceutiques Francaises. Vol. 22, Pg. 523, 1964.
rabbit LD50 rectal 150mg/kg (150mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Annales Pharmaceutiques Francaises. Vol. 22, Pg. 523, 1964.
rat LD50 intraperitoneal 25mg/kg (25mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Annales Pharmaceutiques Francaises. Vol. 22, Pg. 523, 1964.
rat LD50 oral 200mg/kg (200mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Annales Pharmaceutiques Francaises. Vol. 22, Pg. 523, 1964.
rat LD50 subcutaneous 140mg/kg (140mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Annales Pharmaceutiques Francaises. Vol. 22, Pg. 523, 1964.