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Substance Name: Saralasin [INN:BAN]
RN: 34273-10-4
UNII: H2AFV2HE66
InChIKey: PFGWGEPQIUAZME-NXSMLHPHSA-N

Note

  • An octapeptide analog of angiotensin II (bovine) with amino acids 1 and 8 replaced with sarcosine and alanine, respectively. It is a highly specific competitive inhibitor of angiotensin II that is used in the diagnosis of HYPERTENSION.

Molecular Formula

  • C42-H65-N13-O10

Molecular Weight

  • 912.0565
 

Classification Codes

  • Angiotensin II Type 1 Receptor Blockers
  • Angiotensin Receptor Antagonists
  • Angiotensin-Converting Enzyme Inhibitors
  • Antihypertensive Agents
  • Cardiovascular Agents
  • Enzyme Inhibitors
  • Protease Inhibitors
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Names and Synonyms

Results Name

  • Saralasin [INN:BAN]

Name of Substance

  • Saralasin
  • Saralasin [INN:BAN]

MeSH Heading

  • Saralasin

Synonyms

  • (1-(N-Methylglycin) 5-L-valin, 8-L-alanin)angiotensin II
  • N-(1-(N-(N-(N-(N-(N2-(N-methylglycly)-L-arginyl)-L-valyl)-L-tyrosyl)-L-valyl)-L-histidyl)-L-prolyl)-L-alanine
  • Saralasin
  • Saralasina
  • Saralasina [INN-Spanish]
  • Saralasine
  • Saralasine [INN-French]
  • Saralasinum
  • Saralasinum [INN-Latin]
  • UNII-H2AFV2HE66

Systematic Name

  • Angiotensin II, 1-(N-methylglycine)-5-L-valine-8-L-alanine-

Registry Numbers

CAS Registry Number

  • 34273-10-4

FDA UNII

  • H2AFV2HE66

Related Registry Number

  • 39698-78-7 (acetate, hydrated)

System Generated Number

  • 0034273104

Structure Descriptors

InChI

1S/C42H65N13O10/c1-22(2)33(53-35(58)28(50-32(57)20-45-6)9-7-15-47-42(43)44)38(61)51-29(17-25-11-13-27(56)14-12-25)36(59)54-34(23(3)4)39(62)52-30(18-26-19-46-21-48-26)40(63)55-16-8-10-31(55)37(60)49-24(5)41(64)65/h11-14,19,21-24,28-31,33-34,45,56H,7-10,15-18,20H2,1-6H3,(H,46,48)(H,49,60)(H,50,57)(H,51,61)(H,52,62)(H,53,58)(H,54,59)(H,64,65)(H4,43,44,47)/t24-,28-,29-,30-,31-,33-,34-/m0/s1

InChIKey

PFGWGEPQIUAZME-NXSMLHPHSA-N

Smiles

CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](C)C(=O)O