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Substance Name: Butirosin A
RN: 34291-02-6
UNII: 285798GUS5
InChIKey: XEQLFNPSYWZPOW-SVRMBHBBSA-N

Note

  • A water-soluble aminoglycosidic antibiotic complex isolated from fermentation filtrates of Bacillus circulans. Two components (A and B) have been separated from the complex. Both are active against many gram-positive and some gram-negative bacteria. ... /Butirosin sulfate/

Molecular Formula

  • C21-H41-N5-O12

Molecular Weight

  • 555.5779
 

Classification Code

  • Drug / Therapeutic Agent
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Names and Synonyms

Name of Substance

  • Butirosin A

Synonyms

  • Ambutyrosin A
  • Ambuyrosin A
  • Butirosin A
  • Butyrosin A
  • UNII-285798GUS5

Systematic Name

  • D-Streptamine, O-2,6-diamino-2,6-dideoxy-alpha-D-glucopyranosyl-(1-4)-O-(beta-D-xylofuranosyl-(1-5))-N(sup 1)-(4-amino-2-hydroxy-1-oxobutyl)-2-deoxy-

Registry Numbers

CAS Registry Number

  • 34291-02-6

FDA UNII

  • 285798GUS5

System Generated Number

  • 0034291026

Structure Descriptors

InChI

1S/C21H41N5O12/c22-2-1-8(28)19(34)26-7-3-6(24)17(37-20-11(25)15(32)13(30)9(4-23)35-20)18(12(7)29)38-21-16(33)14(31)10(5-27)36-21/h6-18,20-21,27-33H,1-5,22-25H2,(H,26,34)/t6-,7+,8-,9+,10+,11+,12-,13+,14-,15+,16+,17+,18+,20+,21-/m0/s1

InChIKey

XEQLFNPSYWZPOW-SVRMBHBBSA-N

Smiles

NCC[C@H](O)C(=O)N[C@@H]1C[C@H](N)[C@@H](O[C@H]2O[C@H](CN)[C@@H](O)[C@H](O)[C@H]2N)[C@H](O[C@@H]3O[C@H](CO)[C@H](O)[C@H]3O)[C@H]1O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 2198mg/kg (2198mg/kg)   "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 1, Pg. 145, 1980.
mouse LD50 intravenous 580mg/kg (580mg/kg)   "Structure-Activity Relationship among the Semisynthetic Antibiotics," Perlman, D., ed., New York, Academic Press, 1977Vol. -, Pg. 239, 1977.
mouse LD50 subcutaneous 3050mg/kg (3050mg/kg)   "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 1, Pg. 145, 1980.