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Substance Name: Acebutolol hydrochloride [USP:JAN]
RN: 34381-68-5
UNII: B025Y34C54
InChIKey: KTUFKADDDORSSI-UHFFFAOYSA-N
Note
- A cardioselective beta-adrenergic antagonist with little effect on the bronchial receptors. The drug has stabilizing and quinidine-like effects on cardiac rhythm as well as weak inherent sympathomimetic action.
Molecular Formula
- C18-H28-N2-O4.Cl-H
Molecular Weight
- 372.8901
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Formulas
- Structure Descriptors
- Toxicity
Classification Codes
- Anti-Adrenergic (beta-Receptor)
- Drug / Therapeutic Agent
- Human Data
- Reproductive Effect
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Names and Synonyms
Name of Substance
- Acebutolol hydrochloride
- Acebutolol hydrochloride [USP:JAN]
Synonyms
- (+-)-3'-Acetyl-4'-(2-hydroxy-3-(isopropylamino)propoxy)butyranilide monohydrochloride
- 3'-Acetyl-4'-(2-hydroxy-3-(isopropylamino)propoxy)butyranilide hydrochloride
- Acebutolol HCl
- Acebutolol hydrochloride
- Butanamide, N-(3-acetyl-4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)phenyl)-, monohydrochloride, (+-)-
- CCRIS 1102
- Diasectral
- dl-1-(2-Acetyl-4-butyramidophenoxy)-2-hydroxy-3-isopropylaminopropane hydrochloride
- EINECS 251-980-3
- HSDB 6524
- IL 17803A
- IL-17803A
- M&B 17,803A
- M&B 17803A
- Neptal
- NSC 757412
- Prent
- Sectral
- UNII-B025Y34C54
- Wesfalin
Systematic Names
- (1)-N-(3-Acetyl-4-(2-hydroxy-3-((isopropyl)amino)propoxy)phenyl)butyramide monohydrochloride
- Acebutolol hydrochloride
- Butyranilide, 3'-acetyl-4'-(2-hydroxy-3-(isopropylamino)propoxy)-, monohydrochloride, (+-)-
Registry Numbers
CAS Registry Number
- 34381-68-5
FDA UNII
- B025Y34C54
Related Registry Number
- 37517-30-9 (Parent)
System Generated Number
- 0034381685
Molecular Formulas
Molecular Formula
- C18-H28-N2-O4.Cl-H
Molecular Formula Fragments
- C18-H28-N2-O4
- Cl-H
- COMPONENT
Structure Descriptors
InChI
InChI=1S/C18H28N2O4.ClH/c1-5-6-18(23)20-14-7-8-17(16(9-14)13(4)21)24-11-15(22)10-19-12(2)3;/h7-9,12,15,19,22H,5-6,10-11H2,1-4H3,(H,20,23);1HInChIKey
KTUFKADDDORSSI-UHFFFAOYSA-NSmiles
Cl.CCCC(=O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 185mg/kg (185mg/kg) | BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: ATAXIA | Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 837, 1978. |
mouse | LD50 | intravenous | 53mg/kg (53mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: ATAXIA | Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 837, 1978. |
mouse | LD50 | oral | 4050mg/kg (4050mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: ATAXIA BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) | Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 837, 1978. |
mouse | LD50 | subcutaneous | 291mg/kg (291mg/kg) | BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) | Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 837, 1978. |
rabbit | LD50 | intravenous | 41mg/kg (41mg/kg) | BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) | Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 837, 1978. |
rabbit | LD50 | oral | 296mg/kg (296mg/kg) | BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 837, 1978. |
rat | LD50 | intraperitoneal | 222mg/kg (222mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: ATAXIA BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) | Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 837, 1978. |
rat | LD50 | intravenous | 103mg/kg (103mg/kg) | BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) | Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 837, 1978. |
rat | LD50 | oral | 6620mg/kg (6620mg/kg) | BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) | Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 837, 1978. |
rat | LD50 | subcutaneous | 1310mg/kg (1310mg/kg) | BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 837, 1978. |
women | LDLo | oral | 360mg/kg (360mg/kg) | CARDIAC: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE | American Journal of Emergency Medicine. Vol. 6, Pg. 512, 1988. |