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Substance Name: Dibekacin [INN:BAN]
RN: 34493-98-6
UNII: 45ZFO9E525
InChIKey: JJCQSGDBDPYCEO-XVZSLQNASA-N

Note

  • Analog of KANAMYCIN with antitubercular as well as broad-spectrum antimicrobial properties.

Molecular Formula

  • C18-H37-N5-O8

Molecular Weight

  • 451.5173
 

Classification Codes

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Drug / Therapeutic Agent
  • Mutation Data
  • Natural Product
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Dibekacin
  • Dibekacin [INN:BAN]

MeSH Heading

  • Dibekacin

Synonyms

  • 3',4'-Dideoxykanamycin B
  • BRN 1441606
  • Debecacin
  • Dibekacin
  • Dibekacina
  • Dibekacina [INN-Spanish]
  • Dibekacine
  • Dibekacine [INN-French]
  • Dibekacinum
  • Dibekacinum [INN-Latin]
  • Dideoxykanamycin B
  • DKB
  • EINECS 252-064-6
  • Icacine
  • Kappati
  • O-3-Amino-3-deoxy-alpha-D-glucopyranosyl-(1-4)-O-(2,6-diamino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranosyl-(1-6))-2-deoxy-L-streptamine
  • Panamicin
  • UNII-45ZFO9E525

Systematic Names

  • D-Streptamine, O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1-6)-O-(2,6-diamino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranosyl)-(1-4)-2-deoxy-
  • Dibekacin

Registry Numbers

CAS Registry Number

  • 34493-98-6

FDA UNII

  • 45ZFO9E525

System Generated Number

  • 0034493986

Structure Descriptors

InChI

InChI=1S/C18H37N5O8/c19-4-6-1-2-7(20)17(28-6)30-15-8(21)3-9(22)16(14(15)27)31-18-13(26)11(23)12(25)10(5-24)29-18/h6-18,24-27H,1-5,19-23H2/t6-,7+,8-,9+,10+,11-,12+,13+,14-,15+,16-,17+,18+/m0/s1

InChIKey

JJCQSGDBDPYCEO-XVZSLQNASA-N

Smiles

NC[C@@H]1CC[C@@H](N)[C@@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)O1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intramuscular 373mg/kg (373mg/kg)   Journal of Pharmacobio-Dynamics. Vol. 4, Pg. 356, 1981.
mouse LD50 intraperitoneal 11960ug/kg (11.96mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 119, 1975.
mouse LD50 intravenous 8950ug/kg (8.95mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 119, 1975.
mouse LD50 oral 763mg/kg (763mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 119, 1975.
mouse LD50 subcutaneous 15980ug/kg (15.98mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 119, 1975.
rat LD50 intraperitoneal 16760ug/kg (16.76mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 119, 1975.
rat LD50 intravenous 12510ug/kg (12.51mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 119, 1975.
rat LD50 oral > 6950mg/kg (6950mg/kg)   Japanese Journal of Antibiotics. Vol. 26, Pg. 221, 1973.
rat LD50 subcutaneous 23870ug/kg (23.87mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 119, 1975.