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Substance Name: Pseudoephedrine hydrochloride [USAN:USP]
RN: 345-78-8
UNII: 6V9V2RYJ8N
InChIKey: BALXUFOVQVENIU-KXNXZCPBSA-N

Note

  • A phenethylamine that is an isomer of EPHEDRINE which has less central nervous system effects and usage is mainly for respiratory tract decongestion.

Molecular Formula

  • C10-H15-N-O.Cl-H

Molecular Weight

  • 201.6954
 

Classification Codes

  • Decongestant
  • Drug / Therapeutic Agent
  • Human Data
  • Pharmaceutic Aid (Tablet and Capsule Diluent)
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Names and Synonyms

Name of Substance

  • Pseudoephedrine hydrochloride [USAN:USP]

Synonyms

  • (+)-Pseudoephedrine hydrochloride
  • 1S,2S-(+)-Pseudoephedrine hydrochloride
  • Benzenemethanol, alpha-(1-(methylamino)ethyl)-, (S-(R*,R*))-, hydrochloride
  • Benzenemethanol, alpha-(1-(methylamino)ethyl)-, hydrochloride, (S-(R*,R*))-
  • Besan
  • CoAdvil
  • CPDD 0050
  • D-(alpha-(1-Methylamino)ethyl)benzyl alcohol hydrochloride
  • D-Pseudoephedrine hydrochloride
  • EC 206-462-1
  • EINECS 206-462-1
  • First sign
  • L(+)-Pseudoephedrine hydrochloride
  • Nexafed
  • Novafed
  • NSC 106567
  • NSC 33634
  • Otrinol
  • PediaCare Decongestant Drops
  • Pseudoephedrine HCl
  • Pseudoephedrine hydrochloride
  • Pseudophedrine hydrochloride
  • Rhinalair
  • Sinufed
  • Sudafed
  • Sudafed 12 Hour
  • Sudafed 24 Hour
  • Sudafed hydrochloride
  • Sudafed Liquid, Children's
  • Sudomyl
  • Sun mark sinus
  • Suphedrine
  • Symptom 2
  • Topcare 12 hour decongestant
  • Tussaphed
  • UNII-6V9V2RYJ8N

Systematic Names

  • Benzenemethanol, alpha-((1S)-1-(methylamino)ethyl)-, hydrochloride (1:1), (alphaS)-
  • Benzenemethanol, alpha-((1S)-1-(methylamino)ethyl)-, hydrochloride, (alphaS)-
  • Benzenemethanol, alpha-(1-(methylamino)ethyl)-, (S-(R*,R*))-, hydrochloride
  • Benzenemethanol, alpha-(1-(methylamino)ethyl)-, hydrochloride, (S-(R*,R*))- (9CI)
  • Benzenemethanol, alpha-(1-(methylamino)ethyl)-, hydrochloride, (S-(theta,theta))-
  • Pseudoephedrine hydrochloride
  • Pseudoephedrine, hydrochloride, L-(+)-

Mixture Names

  • Actifed
  • Actifed Plus
  • Actifed Sinus Daytime
  • Actifed Sinus Nighttime
  • Actifed with Codeine Cough Syrup
  • Advil Cold & Sinus
  • Advil Cold and Sinus
  • Bayer Select Allergy-Sinus
  • Bayer Select Flu Relief
  • Bayer Select Head & Chest Cold
  • Bayer Select Head Cold
  • Bayer Select Night Time Cold
  • Bayer Select Sinus Pain Relief
  • Brexin EX
  • Brexin L.A.
  • Co-Pyronil 2
  • Congestac
  • Contac Day & Night Allergy Sinus Day Caplets
  • Contac Day & Night Allergy Sinus Night Caplets
  • Contac Day & Night Cold/Flu Day Caplets
  • Contac Day & Night Cold/Flu Night Caplets
  • Contac Jr. Non-drowsy Formula
  • Contac Nighttime Cold Medicine
  • Contac Severe Cold Formula Non-Drowsy
  • Deconamine
  • Deconsal II
  • Dimacol
  • Dimetapp Decongestant
  • Dorcol
  • Dristan Allergy
  • Dristan Cold Maximum Strength Multi-Symptom
  • Dristan Cold No Drowsiness
  • Dristan Sinus
  • Drixoral Cough & Congestion
  • Histalet Syrup
  • Histalet X Tablets
  • Intensin
  • Lodrane LD
  • Lodrane Liquid
  • Mucinex D
  • Naldegesic
  • Nasatab LA
  • Nucofed
  • Ornex and Maximum Strength Ornex
  • Ornex Severe Cold Formula
  • PediaCare Cold Formula
  • PediaCare Cough-Cold Formula
  • Phenergan-D
  • Robitussin Cold & Cough
  • Robitussin Maximum Strength Cough & Cold
  • Robitussin Night Relief
  • Robitussin PE
  • Robitussin Pediatric Cough & Cold
  • Robitussin Pediatric Night Relief
  • Robitussin Severe Congestion
  • Rondec
  • Rondec DM
  • Ru-Tuss DE Tablets
  • Ru-Tuss Expectorant
  • Semprex-D
  • Sine-Aid IB Caplets
  • Sine-Aid, Maximum Strength
  • Sine-Off Maximum Strength Allergy/Sinus
  • Sine-Off Maximum Strength No Drowsiness Formula Caplets
  • Sine-Off Sinus Medicine Caplets
  • Sudafed Cold and Cough
  • Sudafed Cough Syrup
  • Sudafed Plus
  • Sudafed Severe Cold Formula
  • Sudafed Sinus
  • TheraFlu
  • Tussar DM
  • Tylenol Allergy Sinus
  • Tylenol Allergy Sinus Night Time Caplets
  • Tylenol Children's Cold Tablets
  • Tylenol Children's Cough Cold Chewable Tablets
  • Tylenol Cold and Flu Multi-Symptom
  • Tylenol Cold and Flu No Drowsiness
  • Tylenol Cold Medication Caplets, Liquid and Tablets
  • Tylenol Cold No Drowsiness
  • Tylenol Cough + Decongestant Liquid
  • Tylenol Flu Night Time Gelcaps
  • Tylenol Flu Night Time Powder
  • Tylenol Flu No Drowsiness Gelcaps
  • Tylenol Sinus Medication, Maximum Strength
  • Viravan
  • Viro-Med

Registry Numbers

CAS Registry Number

  • 345-78-8

FDA UNII

  • 6V9V2RYJ8N

Other Registry Number

  • 6272-89-5

System Generated Number

  • 0000345788

Molecular Formulas

Molecular Formula

  • C10-H15-N-O.Cl-H

Molecular Formula Fragments

  • C10-H15-N-O
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C10H15NO.ClH/c1-8(11-2)10(12)9-6-4-3-5-7-9;/h3-8,10-12H,1-2H3;1H/t8-,10+;/m0./s1

InChIKey

BALXUFOVQVENIU-KXNXZCPBSA-N

Smiles

Cl.CN[C@@H](C)[C@@H](O)c1ccccc1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
frog LDLo parenteral 800mg/kg (800mg/kg)   "Medical and Biologic Effects of Environmental Pollutants Series," Washington, DC, National Academy of Sciences, 1972-77Vol. Mn, Pg. 128, 1973.
human TDLo oral 714ug/kg (0.714mg/kg) VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION Archives of Internal Medicine. Vol. 39, Pg. 404, 1927.
mouse LD50 intraperitoneal 202mg/kg (202mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 158, Pg. 135, 1967.
mouse LD50 oral 371mg/kg (371mg/kg)   Journal of Pharmaceutical Sciences. Vol. 60, Pg. 1523, 1971.
mouse LDLo parenteral 400mg/kg (400mg/kg)   Manshu Igaku Zasshi. Manchuria Medical Journal. Vol. 3, Pg. 1, 1925.
rabbit LDLo intravenous 75mg/kg (75mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 36, Pg. 363, 1929.
rat LDLo subcutaneous 80mg/kg (80mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 71, Pg. 62, 1941.