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Substance Name: Ketotifen [INN:BAN]
RN: 34580-13-7
UNII: X49220T18G
InChIKey: ZCVMWBYGMWKGHF-UHFFFAOYSA-N
Note
- A cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators. It has been proposed for the treatment of asthma, rhinitis, skin allergies, and anaphylaxis.
Molecular Formula
- C19-H19-N-O-S
Molecular Weight
- 309.4311
Classification Codes
- Anti-Allergic Agents
- Antipruritics
- Dermatologic Agents
- Drug / Therapeutic Agent
- Histamine Agents
- Histamine Antagonists
- Histamine H1 Antagonists
- Neurotransmitter Agents
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Names and Synonyms
Name of Substance
- Ketotifen
- Ketotifen [INN:BAN]
MeSH Heading
- Ketotifen
Synonyms
- 4,9-Dihydro-4-(1-methyl-4-piperidinylidene)-10H-benzo(4,5)cyclohepta(1,2-b)thiophen-10-one
- BRN 3983897
- EINECS 252-099-7
- HC 20-511
- HSDB 7283
- Ketotifen
- Ketotifene
- Ketotifene [INN-French]
- Ketotifeno
- Ketotifeno [INN-Spanish]
- Ketotifenum
- Ketotifenum [INN-Latin]
- UNII-X49220T18G
Systematic Names
- 10H-Benzo(4,5)cyclohepta(1,2-b)thiophen-10-one, 4,9-dihydro-4-(1-methyl-4-piperidinylidene)-
- Ketotifen
Registry Numbers
CAS Registry Number
- 34580-13-7
FDA UNII
- X49220T18G
Other Registry Number
- 116655-74-4
System Generated Number
- 0034580137
Structure Descriptors
InChI
1S/C19H19NOS/c1-20-9-6-13(7-10-20)18-15-5-3-2-4-14(15)12-17(21)19-16(18)8-11-22-19/h2-5,8,11H,6-7,9-10,12H2,1H3InChIKey
ZCVMWBYGMWKGHF-UHFFFAOYSA-NSmiles
CN1CCC(=C2c3ccccc3CC(=O)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 108mg/kg (108mg/kg) | Journal of Medicinal Chemistry. Vol. 30, Pg. 13, 1987. | |
| mouse | LD50 | oral | 179mg/kg (179mg/kg) | Journal of Medicinal Chemistry. Vol. 30, Pg. 13, 1987. |