Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Ketotifen fumarate [USAN:JAN]
RN: 34580-14-8
UNII: HBD503WORO
InChIKey: YNQQEYBLVYAWNX-WLHGVMLRSA-N

Note

  • A cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators. It has been proposed for the treatment of asthma, rhinitis, skin allergies, and anaphylaxis.

Molecular Formula

  • C19-H19-N-O-S.C4-H4-O4

Molecular Weight

  • 425.5027
 

Classification Codes

  • Anti-Asthmatic
  • Drug / Therapeutic Agent
  • Human Data

Names and Synonyms

Name of Substance

  • Ketotifen fumarate [USAN:JAN]

Synonyms

  • 4,9-Dihydro-4-(1-methyl-4-piperidylidene)-10H-benzo(4,5)cyclohepta(1,2-b)thiophen-10-one fumarate (1:1)
  • Alaway
  • EINECS 252-100-0
  • HC 20,511 fumarate
  • Ketotifen
  • Ketotifen fumarate
  • Ketotifen hydrogen fumarate
  • UNII-HBD503WORO
  • Zaditen
  • Zaditor

Systematic Names

  • 10H-Benzo(4,5)cyclohepta(1,2-b)thiophen-10-one, 4,9-dihydro-4-(1-methyl-4-piperidinylidene)-, (E)-2-butenedioate (1:1)
  • 4,9-Dihydro-4-(1-methylpiperidin-4-ylidene)-10H-benzo(4,5)cyclohepta(1,2-b)thiophene-10-one fumarate

Registry Numbers

CAS Registry Number

  • 34580-14-8

FDA UNII

  • HBD503WORO

Other Registry Number

  • 126939-14-8

System Generated Number

  • 0034580148

Molecular Formulas

Molecular Formula

  • C19-H19-N-O-S.C4-H4-O4

Molecular Formula Fragments

  • C19-H19-N-O-S
  • C4-H4-O4
  • COMPONENT

Structure Descriptors

InChI

1S/C19H19NOS.C4H4O4/c1-20-9-6-13(7-10-20)18-15-5-3-2-4-14(15)12-17(21)19-16(18)8-11-22-19;5-3(6)1-2-4(7)8/h2-5,8,11H,6-7,9-10,12H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1+

InChIKey

YNQQEYBLVYAWNX-WLHGVMLRSA-N

Smiles

CN1CCC(=C2c3ccccc3CC(=O)c4c2ccs4)CC1.C(=C/C(=O)O)\C(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo oral 200ug/kg (0.2mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Drug Safety. Vol. 7, Pg. 387, 1992.
child TDLo oral 500ug/kg (0.5mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Drug Safety. Vol. 7, Pg. 387, 1992.
child TDLo oral 500ug/kg (0.5mg/kg) CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Drug Safety. Vol. 7, Pg. 387, 1992.
child TDLo oral 1mg/kg (1mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS Drug Safety. Vol. 7, Pg. 387, 1992.
man TDLo oral 286ug/kg (0.286mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

CARDIAC: PULSE RATE
Drug Safety. Vol. 7, Pg. 387, 1992.
mouse LD50 intravenous 18800ug/kg (18.8mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 4069, 1979.
mouse LD50 oral 585mg/kg (585mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 4069, 1979.
mouse LD50 subcutaneous 820mg/kg (820mg/kg) BLOOD: CHANGES IN SPLEEN

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA
Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 4069, 1979.
rat LD50 intravenous 5100ug/kg (5.1mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 4069, 1979.
rat LD50 oral 360mg/kg (360mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 4069, 1979.
rat LD50 subcutaneous 370mg/kg (370mg/kg) BEHAVIORAL: ATAXIA

SENSE ORGANS AND SPECIAL SENSES: CHROMODACYRORREA: EYE

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 4069, 1979.
women TDLo oral 500ug/kg (0.5mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: GENERAL ANESTHETIC
Drug Safety. Vol. 7, Pg. 387, 1992.