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Substance Name: Zipeprol dihydrochloride
RN: 34758-84-4
UNII: U6WT9D8ASL
InChIKey: MJKMHVIKCKUYTR-UHFFFAOYSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Human Data

Molecular Formulas

  • C23-H32-N2-O3
  • C23-H32-N2-O3.2Cl-H

Molecular Weight

  • 457.4386
 
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Names and Synonyms

Name of Substance

  • Zipeprol dihydrochloride

Synonyms

  • 1-(2-Hydroxy-3-methoxy-3-phenylpropyl)-4-(2-methoxy-2-phenylethyl)piperazine dihydrochloride
  • 1-(2-Methoxy-2-phenyl)ethyl-4-(2-hydroxy-3-methoxy-3-phenyl)propylpiperazine dihydrochlroide
  • 3024 Cerm
  • EINECS 252-192-2
  • Respilene
  • UNII-U6WT9D8ASL
  • Zipeprol
  • Zipeprol dihydrochloride
  • Zipeprol HCl
  • Zitoxil

Systematic Names

  • 1-Piperazineethanol, alpha-(alpha-methoxybenzyl)-4-(beta-methoxyphenethyl)-, dihydrochloride
  • alpha-(Methoxybenzyl)-4-(2-methoxyphenetyl)piperazine-1-ethanol dihydrochloride

Registry Numbers

CAS Registry Number

  • 34758-84-4

FDA UNII

  • U6WT9D8ASL

Related Registry Number

  • 34758-83-3 (Parent)

System Generated Number

  • 0034758844

Molecular Formulas

Molecular Formulas

  • C23-H32-N2-O3
  • C23-H32-N2-O3.2Cl-H

Molecular Formula Fragments

  • C23-H32-N2-O3
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C23H32N2O3.2ClH/c1-27-22(19-9-5-3-6-10-19)18-25-15-13-24(14-16-25)17-21(26)23(28-2)20-11-7-4-8-12-20;;/h3-12,21-23,26H,13-18H2,1-2H3;2*1H

InChIKey

MJKMHVIKCKUYTR-UHFFFAOYSA-N

Smiles

COC(CN1CCN(CC1)CC(C(c2ccccc2)OC)O)c3ccccc3.Cl.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo oral 154mg/kg/3D-I (154mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Lancet. Vol. 1, Pg. 45, 1984.
dog LD50 oral 228mg/kg (228mg/kg) BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Oyo Yakuri. Pharmacometrics. Vol. 22, Pg. 355, 1981.
dog LDLo intravenous 54600ug/kg (54.6mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 523, 1976.
human TDLo oral 11mg/kg (11mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: COMA
Lancet. Vol. 1, Pg. 45, 1984.
man TDLo oral 10714ug/kg (10.714mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Lancet. Vol. 1, Pg. 45, 1984.
mouse LD50 intraperitoneal 116mg/kg (116mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS
Oyo Yakuri. Pharmacometrics. Vol. 22, Pg. 355, 1981.
mouse LD50 intravenous 44300mg/kg (44300mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS
Oyo Yakuri. Pharmacometrics. Vol. 22, Pg. 355, 1981.
mouse LD50 oral 300mg/kg (300mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 523, 1976.
mouse LD50 subcutaneous 158mg/kg (158mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS
Oyo Yakuri. Pharmacometrics. Vol. 22, Pg. 355, 1981.
rabbit LD50 oral 173mg/kg (173mg/kg) BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Oyo Yakuri. Pharmacometrics. Vol. 22, Pg. 355, 1981.
rat LD50 intraperitoneal 77600ug/kg (77.6mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS
Oyo Yakuri. Pharmacometrics. Vol. 22, Pg. 355, 1981.
rat LD50 intravenous 32700ug/kg (32.7mg/kg) BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Oyo Yakuri. Pharmacometrics. Vol. 22, Pg. 355, 1981.
rat LD50 oral 435mg/kg (435mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS
Oyo Yakuri. Pharmacometrics. Vol. 22, Pg. 355, 1981.
rat LD50 subcutaneous 139mg/kg (139mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS
Oyo Yakuri. Pharmacometrics. Vol. 22, Pg. 355, 1981.
women TDLo oral 18mg/kg (18mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Lancet. Vol. 1, Pg. 45, 1984.