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Substance Name: 1,4-Dithiothreitol
RN: 3483-12-3
UNII: T8ID5YZU6Y
InChIKey: VHJLVAABSRFDPM-IMJSIDKUSA-N

Note

  • A reagent commonly used in biochemical studies as a protective agent to prevent the oxidation of SH (thiol) groups and for reducing disulphides to dithiols.

Molecular Formula

  • C4-H10-O2-S2

Molecular Weight

  • 154.253
 

Classification Codes

  • Drug / Therapeutic Agent
  • Mutation Data
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Names and Synonyms

Name of Substance

  • 1,4-Dithiothreitol
  • Dithiothreitol

MeSH Heading

  • Dithiothreitol

Synonyms

  • (R*,R*)-(+-)-1,4-Dimercapto-2,3-butanediol
  • 1,4-Dithiothreitol
  • 2,3-Butanediol, 1,4-dimercapto-, DL-threo-
  • 3-01-00-02360 (Beilstein Handbook Reference)
  • AI3-62064
  • BRN 1719757
  • CCRIS 3617
  • Cleland reagent
  • Cleland's reagent
  • D-1,4-Dithiothreitol
  • D-threo-1,4-Dimercapto-2,3-butanediol
  • Dithiothreitol
  • Dithiotreitol
  • DL-threo-1,4-Dimercapto-2,3-butanediol
  • EINECS 222-468-7
  • EINECS 248-531-9
  • rac-Dithiothreitol
  • Sputolysin
  • Threitol, 1,4-dithio-
  • UNII-T8ID5YZU6Y
  • WR 34678

Systematic Names

  • (R*,R*)-(1)-1,4-Dimercaptobutane-2,3-diol
  • (R*,R*)-1,4-Dimercaptobutane-2,3-diol
  • 2,3-Butanediol, 1,4-dimercapto-, (2R,3R)-rel-
  • 2,3-Butanediol, 1,4-dimercapto-, (R*,R*)- (+-)- (9CI)
  • 2,3-Butanediol, 1,4-dimercapto-, (theta,theta)-(+/-)-
  • 2,3-Butanediol, 1,4-dimercapto-, D-threo-
  • Dithiothreitol
  • Threitol, 1,4-dithio-, DL-

Registry Numbers

CAS Registry Number

  • 3483-12-3

FDA UNII

  • T8ID5YZU6Y

Other Registry Numbers

  • 1377983-58-8
  • 214119-27-4
  • 27565-41-9
  • 28823-08-7

System Generated Number

  • 0003483123

Structure Descriptors

InChI

1S/C4H10O2S2/c5-3(1-7)4(6)2-8/h3-8H,1-2H2/t3-,4-/m0/s1

InChIKey

VHJLVAABSRFDPM-IMJSIDKUSA-N

Smiles

O[C@@H](CS)[C@@H](O)CS

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intramuscular 108mg/kg (108mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Journal of Pharmacy and Pharmacology. Vol. 1, Pg. 576, 1949.
mouse LD50 intraperitoneal 154mg/kg (154mg/kg)   Yakugaku Zasshi. Journal of Pharmacy. Vol. 94, Pg. 1419, 1974.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 42.5 deg C   EXP
log P (octanol-water) -0.480 (none)   EST
Atmospheric OH Rate Constant 1.04E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.