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Substance Name: Bupropion [INN:BAN]
RN: 34911-55-2
UNII: 01ZG3TPX31
InChIKey: SNPPWIUOZRMYNY-UHFFFAOYSA-N

Note

  • A propiophenone-derived antidepressant and antismoking agent that inhibits the uptake of DOPAMINE.

Molecular Formula

  • C13-H18-Cl-N-O

Molecular Weight

  • 239.7442
 

Classification Codes

  • Antidepressive Agents
  • Antidepressive Agents, Second-Generation
  • Central Nervous System Agents
  • Cytochrome P-450 CYP2D6 Inhibitors
  • Cytochrome P-450 Enzyme Inhibitors
  • Dopamine Agents
  • Dopamine Uptake Inhibitors
  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
  • Membrane Transport Modulators
  • Metabolic Side Effects of Drugs and Substances
  • Neurotransmitter Agents
  • Neurotransmitter Uptake Inhibitors
  • Psychotropic Drugs
  • Smoking Cessation Agents

Names and Synonyms

Name of Substance

  • Bupropion [INN:BAN]

MeSH Heading

  • Bupropion

Synonyms

  • (+-)-1-(3-Chlorophenyl)-2-((1,1-dimethylethyl)amino)-1-propanone
  • (+-)-2-(tert-Butylamino)-3'-chloropropiophenone
  • (+-)-2-(tert-Butylamino)-3'-chlorpropiophenon
  • (+-)-Bupropion
  • alpha-(tert-Butylamino)-m-chloropropiophenone
  • Amfebutamon
  • Amfebutamona
  • Amfebutamona [INN-Spanish]
  • Amfebutamone
  • Amfebutamonum
  • Amfebutamonum [INN-Latin]
  • BRN 2101062
  • Bupropion
  • Bupropion SR
  • Elontril
  • HSDB 6988
  • NSC 758686
  • UNII-01ZG3TPX31

Systematic Name

  • 1-Propanone, 1-(3-chlorophenyl)-2-((1,1-dimethylethyl)amino)-, (+-)-

Registry Numbers

CAS Registry Number

  • 34911-55-2

FDA UNII

  • 01ZG3TPX31

Other Registry Number

  • 34841-39-9

System Generated Number

  • 0034911552

Structure Descriptors

InChI

InChI=1S/C13H18ClNO/c1-9(15-13(2,3)4)12(16)10-6-5-7-11(14)8-10/h5-9,15H,1-4H3

InChIKey

SNPPWIUOZRMYNY-UHFFFAOYSA-N

Smiles

CC(NC(C)(C)C)C(=O)c1cccc(Cl)c1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 660mg/kg/22W- (660mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

LIVER: LIVER FUNCTION TESTS IMPAIRED
Journal of Clinical Pyschopharmacology. Vol. 19, Pg. 185, 1999.
mouse LD50 oral 544mg/kg (544mg/kg)   Drug Development Research. Vol. 3, Pg. 357, 1983.