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Substance Name: Bupropion [INN:BAN]
RN: 34911-55-2
UNII: 01ZG3TPX31
InChIKey: SNPPWIUOZRMYNY-UHFFFAOYSA-N
Note
- A propiophenone-derived antidepressant and antismoking agent that inhibits the uptake of DOPAMINE.
Molecular Formula
- C13-H18-Cl-N-O
Molecular Weight
- 239.7442
Classification Codes
- Antidepressive Agents
- Antidepressive Agents, Second-Generation
- Central Nervous System Agents
- Cytochrome P-450 CYP2D6 Inhibitors
- Cytochrome P-450 Enzyme Inhibitors
- Dopamine Agents
- Dopamine Uptake Inhibitors
- Drug / Therapeutic Agent
- Enzyme Inhibitors
- Membrane Transport Modulators
- Metabolic Side Effects of Drugs and Substances
- Neurotransmitter Agents
- Neurotransmitter Uptake Inhibitors
- Psychotropic Drugs
- Smoking Cessation Agents
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Names and Synonyms
Name of Substance
- Bupropion [INN:BAN]
MeSH Heading
- Bupropion
Synonyms
- (+-)-1-(3-Chlorophenyl)-2-((1,1-dimethylethyl)amino)-1-propanone
- (+-)-2-(tert-Butylamino)-3'-chloropropiophenone
- (+-)-2-(tert-Butylamino)-3'-chlorpropiophenon
- (+-)-Bupropion
- alpha-(tert-Butylamino)-m-chloropropiophenone
- Amfebutamon
- Amfebutamona
- Amfebutamona [INN-Spanish]
- Amfebutamone
- Amfebutamonum
- Amfebutamonum [INN-Latin]
- BRN 2101062
- Bupropion
- Bupropion SR
- Elontril
- HSDB 6988
- NSC 758686
- UNII-01ZG3TPX31
Systematic Name
- 1-Propanone, 1-(3-chlorophenyl)-2-((1,1-dimethylethyl)amino)-, (+-)-
Registry Numbers
CAS Registry Number
- 34911-55-2
FDA UNII
- 01ZG3TPX31
Other Registry Number
- 34841-39-9
System Generated Number
- 0034911552
Structure Descriptors
InChI
InChI=1S/C13H18ClNO/c1-9(15-13(2,3)4)12(16)10-6-5-7-11(14)8-10/h5-9,15H,1-4H3InChIKey
SNPPWIUOZRMYNY-UHFFFAOYSA-NSmiles
CC(NC(C)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
man | TDLo | oral | 660mg/kg/22W- (660mg/kg) | BEHAVIORAL: MUSCLE WEAKNESS LIVER: LIVER FUNCTION TESTS IMPAIRED | Journal of Clinical Pyschopharmacology. Vol. 19, Pg. 185, 1999. |
mouse | LD50 | oral | 544mg/kg (544mg/kg) | Drug Development Research. Vol. 3, Pg. 357, 1983. |