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Substance Name: Bupropion [INN:BAN]
RN: 34911-55-2
UNII: 01ZG3TPX31
InChIKey: SNPPWIUOZRMYNY-UHFFFAOYSA-N

Note

  • A unicyclic, aminoketone antidepressant. The mechanism of its therapeutic actions is not well understood, but it does appear to block dopamine uptake. The hydrochloride is available as an aid to smoking cessation treatment.

Molecular Formula

  • C13-H18-Cl-N-O

Molecular Weight

  • 239.7442
 

Classification Codes

  • Antidepressive Agents
  • Antidepressive Agents, Second-Generation
  • Central Nervous System Agents
  • Cytochrome P-450 CYP2D6 Inhibitors
  • Cytochrome P-450 Enzyme Inhibitors
  • Dopamine Agents
  • Dopamine Uptake Inhibitors
  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
  • Membrane Transport Modulators
  • Neurotransmitter Agents
  • Neurotransmitter Uptake Inhibitors
  • Psychotropic Drugs

Names and Synonyms

Name of Substance

  • Bupropion [INN:BAN]

MeSH Heading

  • Bupropion

Synonyms

  • (+-)-1-(3-Chlorophenyl)-2-((1,1-dimethylethyl)amino)-1-propanone
  • (+-)-2-(tert-Butylamino)-3'-chloropropiophenone
  • (+-)-2-(tert-Butylamino)-3'-chlorpropiophenon
  • (+-)-Bupropion
  • alpha-(tert-Butylamino)-m-chloropropiophenone
  • Amfebutamon
  • Amfebutamona
  • Amfebutamona [INN-Spanish]
  • Amfebutamone
  • Amfebutamonum
  • Amfebutamonum [INN-Latin]
  • BRN 2101062
  • Bupropion
  • Bupropion SR
  • Elontril
  • HSDB 6988
  • UNII-01ZG3TPX31

Systematic Name

  • 1-Propanone, 1-(3-chlorophenyl)-2-((1,1-dimethylethyl)amino)-, (+-)-

Registry Numbers

CAS Registry Number

  • 34911-55-2

FDA UNII

  • 01ZG3TPX31

Other Registry Number

  • 34841-39-9

System Generated Number

  • 0034911552

Structure Descriptors

InChI

1S/C13H18ClNO/c1-9(15-13(2,3)4)12(16)10-6-5-7-11(14)8-10/h5-9,15H,1-4H3

InChIKey

SNPPWIUOZRMYNY-UHFFFAOYSA-N

Smiles

CC(C(=O)c1cccc(c1)Cl)NC(C)(C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 660mg/kg/22W- (660mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

LIVER: LIVER FUNCTION TESTS IMPAIRED
Journal of Clinical Pyschopharmacology. Vol. 19, Pg. 185, 1999.
mouse LD50 oral 544mg/kg (544mg/kg)   Drug Development Research. Vol. 3, Pg. 357, 1983.