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Substance Name: H-88
RN: 34929-08-3
InChIKey: YKVDSZPXGNPCRO-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C17-H13-F3-N2-O3

Molecular Weight

  • 350.295
 
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Names and Synonyms

Name of Substance

  • H-88

Synonyms

  • 1-(m-Trifluoromethylphenyl)-3-(2'-hydroxyethyl)quinazoline-2,4-dione
  • 1-(m-Trifluoromethylphenyl)-3-(2-hydroxyethyl)-quinazoline-2,4(1H,3H)-dione
  • 3-(2-Hydroxyethyl)-1-(3-(trifluoromethyl)phenyl)-2,4(1H,3H)-quinazolinedione
  • 5-24-07-00496 (Beilstein Handbook Reference)
  • BRN 0766834
  • H-88

Systematic Names

  • 2,4(1H,3H)-Quinazolinedione, 3-(2-hydroxyethyl)-1-(m-(trifluoromethyl)phenyl)-
  • 3-(2-Hydroxyethyl)-1-(3-(trifluoromethyl)phenyl)-2,4(lH,3H)-quinazolinedione

Registry Numbers

CAS Registry Number

  • 34929-08-3

System Generated Number

  • 0034929083

Structure Descriptors

InChI

1S/C17H13F3N2O3/c18-17(19,20)11-4-3-5-12(10-11)22-14-7-2-1-6-13(14)15(24)21(8-9-23)16(22)25/h1-7,10,23H,8-9H2

InChIKey

YKVDSZPXGNPCRO-UHFFFAOYSA-N

Smiles

n1(c(n(c(c2ccccc12)=O)CCO)=O)c1cc(ccc1)C(F)(F)F

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral > 2gm/kg (2000mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: ATAXIA

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 501, 1978.
guinea pig LD50 oral 320mg/kg (320mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 501, 1978.
hamster LD50 oral > 2gm/kg (2000mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: ATAXIA

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 501, 1978.
mouse LD50 intraperitoneal 200mg/kg (200mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: MALABSORPTION

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 70, Pg. 673, 1974.
mouse LD50 oral 630mg/kg (630mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: ATAXIA

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 501, 1978.
rabbit LD50 oral > 2500mg/kg (2500mg/kg) BEHAVIORAL: ATAXIA

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 501, 1978.
rat LD50 intraperitoneal 152mg/kg (152mg/kg) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

GASTROINTESTINAL: MALABSORPTION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 70, Pg. 673, 1974.
rat LD50 oral 810mg/kg (810mg/kg)   Drugs of the Future. Vol. 4, Pg. 201, 1979.
rat LD50 subcutaneous > 2gm/kg (2000mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 501, 1978.