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Substance Name: Timepidium bromide [INN:JAN]
RN: 35035-05-3
UNII: 8R9E4766V4
InChIKey: QTSXMEPZSHLZFF-UHFFFAOYSA-M

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formulas

  • C17-H22-Br-N-O-S2
  • C17-H22-N-O-S2.Br

Molecular Weight

  • 400.403
 
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Names and Synonyms

Name of Substance

  • Timepidium bromide
  • Timepidium bromide [INN:JAN]

Synonyms

  • 1,1-Dimethyl-5-methoxy-3-(dithien-2-ylmethylene)-piperidinium bromide
  • Bromure de timepidium
  • Bromure de timepidium [INN-French]
  • Bromuro de timepidio
  • Bromuro de timepidio [INN-Spanish]
  • N-Methyl-5-methoxy-3-piperidylidenedithienylmethane methobromide
  • SA 50 Y
  • SA 504
  • Timepidii bromidum
  • Timepidii bromidum [INN-Latin]
  • Timepidium bromide
  • UNII-8R9E4766V4

Systematic Names

  • 3-(Di-2-thienylmethylene)-5-methoxy-1,1-dimethyl-piperidinium bromide
  • Piperidinium, 3-(di-2-thienylmethylene)-5-methoxy-1,1-dimethyl-, bromide

Registry Numbers

CAS Registry Number

  • 35035-05-3

FDA UNII

  • 8R9E4766V4

System Generated Number

  • 0035035053

Molecular Formulas

Molecular Formulas

  • C17-H22-Br-N-O-S2
  • C17-H22-N-O-S2.Br

Molecular Formula Fragments

  • Br
  • C17-H22-N-O-S2
  • COMPONENT

Structure Descriptors

InChI

1S/C17H22NOS2.BrH/c1-18(2)11-13(10-14(12-18)19-3)17(15-6-4-8-20-15)16-7-5-9-21-16;/h4-9,14H,10-12H2,1-3H3;1H/q+1;/p-1

InChIKey

QTSXMEPZSHLZFF-UHFFFAOYSA-M

Smiles

[N+]1(C\C(C[C@@H](C1)OC)=C(/c1cccs1)c1cccs1)(C)C.[BrH-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intramuscular 199mg/kg (199mg/kg)   Drugs in Japan Vol. 6, Pg. 351, 1982.
mouse LD50 intraperitoneal 97mg/kg (97mg/kg) GASTROINTESTINAL: OTHER CHANGES

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Journal of Medicinal Chemistry. Vol. 15, Pg. 914, 1972.
mouse LD50 intravenous 12mg/kg (12mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Japanese Journal of Pharmacology. Vol. 22, Pg. 685, 1972.
mouse LD50 oral 713mg/kg (713mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

GASTROINTESTINAL: OTHER CHANGES

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Journal of Medicinal Chemistry. Vol. 15, Pg. 914, 1972.
mouse LD50 subcutaneous 145mg/kg (145mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE
Japanese Journal of Pharmacology. Vol. 22, Pg. 685, 1972.
rat LD50 intramuscular 324mg/kg (324mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 17, Pg. 2087, 1975.
rat LD50 intraperitoneal 55mg/kg (55mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Japanese Journal of Pharmacology. Vol. 22, Pg. 685, 1972.
rat LD50 intravenous 7mg/kg (7mg/kg) AUTONOMIC NERVOUS SYSTEM: "SMOOTH MUSCLE RELAXANT (MECHANISM UNDEFINED, SPASMOLYTIC)"

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE
Oyo Yakuri. Pharmacometrics. Vol. 23, Pg. 461, 1982.
rat LD50 oral 1213mg/kg (1213mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Japanese Journal of Pharmacology. Vol. 22, Pg. 685, 1972.
rat LD50 subcutaneous 254mg/kg (254mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Japanese Journal of Pharmacology. Vol. 22, Pg. 685, 1972.