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Substance Name: Epoprostenol [USAN:INN]
RN: 35121-78-9
UNII: DCR9Z582X0
InChIKey: KAQKFAOMNZTLHT-OZUDYXHBSA-N

Note

  • A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from PROSTAGLANDIN ENDOPEROXIDES in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension (HYPERTENSION, PULMONARY).

Molecular Formula

  • C20-H32-O5

Molecular Weight

  • 352.4678
 

Classification Codes

  • Antihypertensive Agents
  • Antiviral (COVID-19)
  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Hematologic Agents
  • Inhibitor (Platelet)
  • Platelet Aggregation Inhibitors
  • Reproductive Effect

Names and Synonyms

Name of Substance

  • Epoprostenol
  • Epoprostenol [USAN:INN]

MeSH Heading

  • Epoprostenol

Synonyms

  • (Z)-(3aR,4R,5R,6aS)-Hexahydro-5-hydroxy-4-((E)-(3S)-3-hydroxy-1-octenyl)-2H-cyclopenta(b)furan-delta(sup 2,delta)-valeric acid
  • 6,9-alpha-Epoxy-11-alpha,15(S)-dihydroxyprosta-5(Z),13(E)-dien-1-oic acid
  • BRN 1690090
  • Epoprostenol
  • Epoprostenolum
  • Epoprostenolum [INN-Latin]
  • Flolan
  • KB-IV-24
  • PGI(sub 2)
  • PGX
  • Prostacyclin
  • Prostaglandin I2
  • Prostaglandin X
  • U 53,217
  • U 53217
  • U-53,217
  • UNII-DCR9Z582X0
  • Vasocyclin
  • VentaProst

Systematic Name

  • Prosta-5,13-dien-1-oic acid, 6,9-epoxy-11,15-dihydroxy-, (5Z,9alpha,11alpha,13E,15S)-

Registry Numbers

CAS Registry Number

  • 35121-78-9

FDA UNII

  • DCR9Z582X0

Other Registry Numbers

  • 63748-50-5
  • 63859-31-4

System Generated Number

  • 0035121789

Structure Descriptors

InChI

InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1

InChIKey

KAQKFAOMNZTLHT-OZUDYXHBSA-N

Smiles

CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)C[C@@H]2O\C(=C/CCCC(=O)O)\C[C@H]12