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Substance Name: Kinamycin C
RN: 35303-08-3
InChIKey: MXDLFLPONIABIS-OLKYXYMISA-N

Note

  • An antineoplastic antibiotic that inhibits topoisomerase IIalpha; isolated from Streptomyces murayamaensis.

Classification Codes

  • Drug / Therapeutic Agent
  • Natural Product

Molecular Formula

  • C24-H20-N2-O10

Molecular Weight

  • 496.426
 
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Names and Synonyms

Results Name

  • Kinamycin C

Synonyms

  • 5-21-13-00704 (Beilstein Handbook Reference)
  • BRN 0505519
  • Kinamycin C
  • NSC 138425

Systematic Name

  • 5H-Benzo(b)carbazole-5-carbonitrile, 1,2,4-tris(acetyloxy)-1,2,3,4,6,11-hexahydro-3,7-dihydroxy-3-methyl-6,11-dioxo-, (1-alpha,2-beta,3-alpha,4-alpha)-

Registry Numbers

CAS Registry Number

  • 35303-08-3

System Generated Number

  • 0035303083

Structure Descriptors

InChI

1S/C24H20N2O10/c1-8(27)34-21-15-14-16(20(32)13-11(19(14)31)6-5-7-12(13)30)18(26-25)17(15)22(35-9(2)28)24(4,33)23(21)36-10(3)29/h5-7,21-23,30,33H,1-4H3/t21-,22+,23+,24+/m0/s1

InChIKey

MXDLFLPONIABIS-OLKYXYMISA-N

Smiles

CC(=O)O[C@H]1c2c3=c(c(=[N+]=[N-])c2[C@H]([C@@]([C@@H]1OC(=O)C)(C)O)OC(=O)C)c(=O)c4c(c3=O)cccc4O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 30mg/kg (30mg/kg)   Journal of Antibiotics. Vol. 23, Pg. 315, 1970.