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Substance Name: Amphotericin B, methyl ester, hydrochloride
RN: 35375-29-2
InChIKey: FCUABMXRRQIKMV-MFVSQRFRSA-N

Molecular Formula

  • C48-H75-N-O17.Cl-H

Molecular Weight

  • 974.571
 
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Names and Synonyms

Synonyms

  • AME hydrochloride
  • NSC 252624

Systematic Name

  • Amphotericin B, methyl ester, hydrochloride

Registry Numbers

CAS Registry Number

  • 35375-29-2

Related Registry Number

  • 36148-89-7 (Parent)

System Generated Number

  • 0035375292

Molecular Formulas

Molecular Formula

  • C48-H75-N-O17.Cl-H

Molecular Formula Fragments

  • C48-H75-N-O17
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C48H75NO17.ClH/c1-28-18-16-14-12-10-8-6-7-9-11-13-15-17-19-35(65-47-45(59)42(49)44(58)31(4)64-47)25-39-41(46(60)62-5)38(55)27-48(61,66-39)26-34(52)23-37(54)36(53)21-20-32(50)22-33(51)24-40(56)63-30(3)29(2)43(28)57;/h6-19,28-39,41-45,47,50-55,57-59,61H,20-27,49H2,1-5H3;1H/b7-6+,10-8+,11-9+,14-12+,15-13+,18-16+,19-17+;/t28-,29-,30-,31+,32+,33+,34-,35-,36+,37+,38-,39-,41+,42-,43+,44+,45-,47-,48+;/m0./s1

InChIKey

FCUABMXRRQIKMV-MFVSQRFRSA-N

Smiles

C1[C@@H](C[C@@H](CC[C@H]([C@H](O)C[C@H](O)C[C@@]2(O[C@@H](C[C@H](C=CC=CC=CC=CC=CC=CC=C[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC1=O)O[C@H]1[C@H]([C@H]([C@@H]([C@H](O1)C)O)N)O)[C@@H]([C@H](C2)O)C(OC)=O)O)O)O)O.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 48mg/kg (48mg/kg)   Science. Vol. 179, Pg. 584, 1973.
mouse LD50 intraperitoneal 1320mg/kg (1320mg/kg)   Science. Vol. 179, Pg. 584, 1973.
mouse LD50 intravenous 75mg/kg (75mg/kg)   "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 2, Pg. 1019, 1978.